DDS and Me

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
Tadanori Mayumi

Abstract

With the success of the human genome project, the focus of life science research has shifted to the functional and structural analyses of proteins, such as proteomics and structural genomics. These analyses of proteins including newly identified proteins are expected to contribute to the identification of therapeutically applicable proteins for various diseases. Thus, pharmaco-proteomic-based drug discovery and development for protein therapies, including gene therapy, cell therapy, and vaccine therapy, is attracting current attention. However, there is clinical difficulty in using almost all bioactive proteins, because of their very low stability and pleiotropic actions in vivo. To promote pharmaco-proteomic-based drug discovery and development, we have attempted to develop drug delivery systems (DDSs), such as the protein-drug innovation system and the optimal cell therapeutic system. In this review, we introduce our original DDSs.

References

Feb 14, 1991·Biochemical and Biophysical Research Communications·K KawasakiT Mayumi
May 1, 1995·Journal of Cellular Physiology·N UtoguchiT Mayumi
Feb 1, 1995·Japanese Journal of Cancer Research : Gann·N UtoguchiT Mayumi
Jan 5, 1996·Biochemical and Biophysical Research Communications·H MizuguchiT Mayumi
Mar 1, 1996·International Journal of Microcirculation, Clinical and Experimental·N UtoguchiT Mayumi
Jan 1, 1997·The Journal of Pharmacy and Pharmacology·R IgarashiY Mizushima
May 8, 1997·Biochemical and Biophysical Research Communications·H MizuguchiT Mayumi
Jul 18, 1997·Biochemical and Biophysical Research Communications·I OhizumiT Mayumi
Dec 17, 1997·Biochemical and Biophysical Research Communications·T NakanishiT Mayumi
Jan 13, 1998·Biochemical and Biophysical Research Communications·M MaedaT Mayumi
Jul 25, 1998·The Biochemical Journal·T UsuiH Osada
Jul 29, 1998·International Journal of Cancer. Journal International Du Cancer·I OhizumiT Mayumi
Aug 15, 1998·Biochemical and Biophysical Research Communications·M MaedaT Mayumi

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