DDX11-AS1 as potential therapy targets for human hepatocellular carcinoma

Oncotarget
Min ShiXiao-Jie Lu

Abstract

Hepatocellular Carcinoma (HCC) is one of the most fatal cancers, whose incidence and death rates are still rising. Here, we report the identification of long non-coding RNAs (IncRNAs) that associated with HCC progression and metabolism based on the systematically analysis of large scale RNA-seq data from HCC patients. We identified seven lncRNAs with high confidence which were highly related with prognostic of HCC. Of note, three of them had quite different expression patterns between the control samples and the patients, and their critical roles in cancer progression were validated. We proposed that DDX11-AS1 play important role during HCC oncogenesis and may serve as potential therapy target for HCC.

References

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Citations

Aug 11, 2020·Human Cell·Yubin FengFeihu Chen
Feb 15, 2020·Artificial Cells, Nanomedicine, and Biotechnology·Zheng RenDesheng Yang
Apr 4, 2021·Genes·Mohammad MahtabFrancesca M Pisani
Oct 21, 2020·Biomedical Journal·Po-Shuan HuangKwang-Huei Lin

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Methods Mentioned

BETA
RNA-seq

Software Mentioned

dbVar
HUGO
ClinVar
Genomic Data Commons
LNCiepdia
HAGLROS
R package limma
LNCipedia
NONCODE

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