DE-cadherin, a core component of the adherens junction complex modifies subcellular localization of the Drosophila gap junction protein innexin2

Cell Communication & Adhesion
R BauerM Hoch

Abstract

The Drosophila innexin multigene family of gap junction encoding proteins consists of eight family members whose function in epithelial morphogenesis is mostly unknown. We have recently shown that innexin2 plays a crucial role in the organization of embryonic epithelia. Innexin2 protein accumulates in the epidermis in the apico-lateral membrane domain and colocalizes with core proteins of adherens junctions, such as DE-cadherin and Armadillo, the ss -catenin homolog. Innexin2 localization is altered in both armadillo and DE-cadherin mutants Biochemical interaction studies point to a direct interaction of DE-cadherin and Armadillo with innexin2 suggesting a close link between gap junction and adherens junction biogenesis. We have used the Drosophila Schneider cell tissue culture system to further study the interaction of innexin2 with DE-cadherin. Our results provide evidence that DE-cadherin may be a key component to control trafficking, and localization of Innexin2 to the plasma membrane.

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Citations

Jan 27, 2006·Molecular Biology of the Cell·Corinna LehmannMichael Hoch
Dec 3, 2011·Journal of Cell Science·Stephanie J AiroldiLynn Cooley
Jul 31, 2013·PloS One·Fabrizio GiulianiCatherine Rabouille
May 4, 2012·Critical Reviews in Biochemistry and Molecular Biology·Jérôme GilleronGeorges Pointis
Oct 13, 2015·Developmental Biology·Mélisande Richard, Michael Hoch
Apr 10, 2017·Developmental Biology·Mélisande RichardMichael Hoch
Mar 19, 2014·FEBS Letters·Daniel K Hasegawa, Matthew W Turnbull
Jul 20, 2020·Insect Molecular Biology·D K HasegawaM W Turnbull
Oct 21, 2016·The Journal of Biological Chemistry·Satoru WakabayashiMichael Hoch
Nov 26, 2020·Developmental Cell·Lingfeng Meng, Dong Yan

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