De novo coccidioidomycosis among solid organ transplant recipients 1 or more years after transplant

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Kara AsburyTirdad T Zangeneh

Abstract

Solid organ transplant recipients who contract coccidioidomycosis are at risk for complicated, protracted, disseminated, and severe disease. To date, no studies have described outcomes for patients who develop coccidioidomycosis only after the first posttransplant year. This study was a joint project of Mayo Clinic Hospital, Phoenix, Arizona, and the University of Arizona/Banner University Medical Center, Tucson, Arizona. We retrospectively reviewed electronic health records for patients with a history of solid organ transplant between January 1, 1998, and October 11, 2014, who developed coccidioidomycosis after the first transplant year. We identified 91 patients. Of those, 37/91 (40.7%) had pulmonary coccidioidomycosis (29/37 [78.4%] were symptomatic); and 5/91 (5.5%) had extrapulmonary disease (all were symptomatic). One patient (1.1%) died. Coccidioidomycosis was evident in 2/91 (2.2%) patients within 3 months of antirejection treatment. Many of the patients (51/91 [56.0%]) had asymptomatic coccidioidomycosis, 27 (27.9%) of whom were followed up closely but did not receive antifungal medication and had no sequelae. Although solid organ recipients taking low-level immunosuppression after the first posttransplant year appeare...Continue Reading

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Citations

Jun 14, 2019·Current Opinion in Organ Transplantation·Deepa D Nanayakkara, Emily Blodget
Sep 1, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Clover N TruongKellie J Goodlet
Oct 2, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Clover N TruongKellie J Goodlet
Nov 6, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Mohanad M Al-ObaidiTirdad T Zangeneh

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