De novo formation of an aggregation pheromone precursor by an isoprenyl diphosphate synthase-related terpene synthase in the harlequin bug

Proceedings of the National Academy of Sciences of the United States of America
Jason LancasterDorothea Tholl

Abstract

Insects use a diverse array of specialized terpene metabolites as pheromones in intraspecific interactions. In contrast to plants and microbes, which employ enzymes called terpene synthases (TPSs) to synthesize terpene metabolites, limited information from few species is available about the enzymatic mechanisms underlying terpene pheromone biosynthesis in insects. Several stink bugs (Hemiptera: Pentatomidae), among them severe agricultural pests, release 15-carbon sesquiterpenes with a bisabolene skeleton as sex or aggregation pheromones. The harlequin bug, Murgantia histrionica, a specialist pest of crucifers, uses two stereoisomers of 10,11-epoxy-1-bisabolen-3-ol as a male-released aggregation pheromone called murgantiol. We show that MhTPS (MhIDS-1), an enzyme unrelated to plant and microbial TPSs but with similarity to trans-isoprenyl diphosphate synthases (IDS) of the core terpene biosynthetic pathway, catalyzes the formation of (1S,6S,7R)-1,10-bisaboladien-1-ol (sesquipiperitol) as a terpene intermediate in murgantiol biosynthesis. Sesquipiperitol, a so-far-unknown compound in animals, also occurs in plants, indicating convergent evolution in the biosynthesis of this sesquiterpene. RNAi-mediated knockdown of MhTPS mRNA co...Continue Reading

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Citations

Feb 7, 2019·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·T EltzT Mende
Dec 14, 2019·Archives of Insect Biochemistry and Physiology·Maria RigaJohn Vontas
Oct 13, 2019·The Journal of Biological Chemistry·Joshua P Torres, Eric W Schmidt
Sep 30, 2018·Journal of Chemical Ecology·Jason LancasterDorothea Tholl
Oct 22, 2019·Frontiers in Plant Science·Prema S Karunanithi, Philipp Zerbe
Sep 24, 2020·ACS Infectious Diseases·Justin J Miller, Audrey R Odom John
Aug 15, 2021·Nature Communications·Likui FengRebecca A Butcher

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Methods Mentioned

BETA
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