De novo generation of HSCs from somatic and pluripotent stem cell sources.

Blood
Linda T Vo, George Q Daley

Abstract

Generating human hematopoietic stem cells (HSCs) from autologous tissues, when coupled with genome editing technologies, is a promising approach for cellular transplantation therapy and for in vitro disease modeling, drug discovery, and toxicology studies. Human pluripotent stem cells (hPSCs) represent a potentially inexhaustible supply of autologous tissue; however, to date, directed differentiation from hPSCs has yielded hematopoietic cells that lack robust and sustained multilineage potential. Cellular reprogramming technologies represent an alternative platform for the de novo generation of HSCs via direct conversion from heterologous cell types. In this review, we discuss the latest advancements in HSC generation by directed differentiation from hPSCs or direct conversion from somatic cells, and highlight their applications in research and prospects for therapy.

References

Dec 1, 1990·Genes & Development·M H Lindenbaum, F Grosveld
Dec 6, 1994·Proceedings of the National Academy of Sciences of the United States of America·G SauvageauR K Humphries
Jan 1, 1993·Molecular and Cellular Biology·G KellerM V Wiles
Jun 24, 1997·Proceedings of the National Academy of Sciences of the United States of America·M C YoderP Mukherjee
Nov 6, 1998·Science·J A ThomsonJ M Jones
Sep 6, 2001·Proceedings of the National Academy of Sciences of the United States of America·D S KaufmanJ A Thomson
Sep 12, 1957·The New England Journal of Medicine·E D THOMASJ W FERREBEE
Oct 11, 2003·Biochemical and Biophysical Research Communications·T MiyatsukaM Hori
May 28, 2004·Cell·Huafeng XieThomas Graf
Apr 5, 2007·Nature Protocols·Hideo EmaHiromitsu Nakauchi
Jun 22, 2007·Immunity·Hiromi Iwasaki, Koichi Akashi
Jan 22, 2008·Nature Immunology·Elaine Dzierzak, Nancy A Speck
Feb 26, 2008·Cell·Stuart H Orkin, Leonard I Zon
Aug 30, 2008·Nature·Qiao ZhouDouglas A Melton
Sep 27, 2008·Current Protocols in Stem Cell Biology·Katherine L Hill, Dan S Kaufman
Dec 2, 2008·Cell Stem Cell·Ann C ZoveinM Luisa Iruela-Arispe
Feb 14, 2009·The New England Journal of Medicine·Gero HütterEckhard Thiel
May 21, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Frank TimmermansBart Vandekerckhove
Aug 26, 2010·Molecular Therapy : the Journal of the American Society of Gene Therapy·Veronica Ramos-MejiaPablo Menendez

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Citations

Oct 6, 2015·Molecular Therapy : the Journal of the American Society of Gene Therapy·Moonjung JungThomas Winkler
Dec 15, 2015·Annals of the New York Academy of Sciences·Aditi VediElisa Laurenti
Nov 4, 2015·Advanced Drug Delivery Reviews·Ryohichi Sugimura
May 21, 2016·Scientific Reports·Eva Garcia-AlegriaKiran Batta
Apr 8, 2016·Blood·Megan D Hoban, Daniel E Bauer
May 29, 2016·International Journal of Hematology·Mark J OsbornDaniel F Voytas
Jun 12, 2016·Biologie aujourd'hui·Christelle Mazurier, Luc Douay
Jul 19, 2016·Nature Communications·Claire S KoechleinTannishtha Reya
Oct 28, 2016·Nature Cell Biology·Lara Wahlster, George Q Daley
Oct 30, 2016·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Leif S LudwigVijay G Sankaran
Nov 24, 2016·Nature Reviews. Molecular Cell Biology·Andrea DitadiGordon Keller
May 17, 2017·Critical Reviews in Biochemistry and Molecular Biology·Jenna RichterKarl Willert
Dec 8, 2019·Nature Reviews. Immunology·Caroline RaffinJeffrey A Bluestone
Oct 18, 2019·Annals of the New York Academy of Sciences·Michael G DanielKateri A Moore
May 1, 2019·Scientific Reports·Walatta-Tseyon MesquittaIgor I Slukvin
Jun 7, 2019·Disease Models & Mechanisms·Maria Georgomanoli, Eirini P Papapetrou
Jun 14, 2019·Stem Cells International·Methichit Wattanapanitch
Jun 15, 2019·Stem Cells International·Akhilesh KumarAbir S Thakur
Feb 10, 2017·Science Translational Medicine·Sergei DoulatovGeorge Q Daley
Aug 28, 2019·Cold Spring Harbor Perspectives in Medicine·Eirini P Papapetrou
Dec 3, 2020·Current Opinion in Hematology·Sergei Doulatov, Eirini P Papapetrou
Jan 4, 2021·Stem Cell Research·Nikolaos Spyrou, Eirini P Papapetrou
Dec 12, 2020·Journal of Hematology & Oncology·Yi ZhouLin Cheng
Feb 17, 2021·Stem Cell Research·Andreea Reilly, Sergei Doulatov
Nov 18, 2020·Stem Cell Research & Therapy·Mohsen EbrahimiMaryam Farzaneh
Feb 19, 2021·Stem Cell Research & Therapy·Kyle LewisTakanori Takebe
Jun 15, 2017·Biochemical and Biophysical Research Communications·Misako MatsushitaMinoru S H Ko
Mar 11, 2021·Med·Stuart H Orkin
Dec 6, 2020·Current Opinion in Hematology·Sergei Doulatov, Eirini P Papapetrou

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