De Novo Malignancy After Heart, Kidney, and Liver Transplant: A Nationwide Study in Taiwan.

Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation
Chun-Chieh YehChien-Chang Liao

Abstract

In the Asian population, patterns and risk factors for de novo malignancies after solid-organ transplant are not well understood. Insurance claims from Taiwan's National Health Institute Research Database from 1997 to 2011 revealed 687 deceased-donor heart transplant recipients, 5038 kidney transplant recipients (50% living related-donor, 50% deceased-donor transplants), and 2127 liver transplant recipients (mainly living related-donor transplants, 30% deceased-donor transplants). During the follow-up period, rates of malignancy incidence were calculated with standardization based on national age, sex, and year-specific incidence. We used multivariate regression analyses to determine risk factors of posttransplant de novo malignancies. Compared with the general population, several de novo cancers were more common posttransplant (P < .05): lung cancer (2.6-fold), non-melanoma skin cancer (5.8-fold), and non-Hodgkin lymphoma (5.4-fold) in heart recipients; transitional cell carcinoma (31.4-fold), renal cell carcinoma (37.3-fold), and non-Hodgkin lymphoma (3.6-fold) in kidney recipients; and gastric cancer (3.0-fold) and lymphatic-hematopoietic malignancy (4.5-fold) in liver recipients. Independent risk factors for posttransplant ...Continue Reading

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Citations

May 15, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Hao L LuoYuan T Cheng
Jul 20, 2021·Journal of Clinical and Experimental Hepatology·Narendra S ChoudharyArvinder S Soin

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