PMID: 11310196Apr 20, 2001Paper

De novo malignant transformation of giant cell tumor of bone

Skeletal Radiology
T MaruiT Akamatsu

Abstract

Two cases of malignant lesions are reported, both of which arose secondary to an originally benign giant cell tumor (GCT) of bone. The first case was a typical benign GCT, which occurred in the left proximal tibia of a 31-year-old woman. The tumor was treated by curettage and bone grafting. However, it recurred twice during 15 years of follow-up. The second recurrence showed that the lesion histologically had turned into malignant fibrous histiocytoma. The second case also started as an initially benign GCT that arose in the left distal femur of a 41-year-old man. The patient underwent curettage and bone grafting. The lesion recurred 13 years postoperatively. The histological appearance of the recurrent tumor showed it to be an osteogenic sarcoma. In both patients, radiation and never been given. Malignant transformation has rarely been reported in patients with GCT of bone who have not received radiation treatment.

Citations

Jun 7, 2003·Annals of Nuclear Medicine·Zeynep YaparMehmet Emin Inal
Oct 3, 2006·International Orthopaedics·Mathias Werner
Oct 1, 1967·Oral Surgery, Oral Medicine, and Oral Pathology·Y RamonJ J Bubis
Jun 2, 1998·The Journal of Hand Surgery : Journal of the British Society for Surgery of the Hand·E P Clarke, J W Pritchett
Jan 26, 2006·The Tohoku Journal of Experimental Medicine·Ko HashimotoShoichi Kokubun
Sep 13, 2001·Radiographics : a Review Publication of the Radiological Society of North America, Inc·M D MurpheyM J Kransdorf
Sep 11, 2010·European Journal of Radiology·Piero PicciMario Mercuri
Jan 21, 2011·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Tomohiko OzakiShusuke Moriuchi
Nov 26, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Esma SaâdaFlorence Pedeutour
Feb 20, 2010·São Paulo Medical Journal = Revista Paulista De Medicina·Rosalvo Zósimo Bispo JúniorCláudia Regina Gomes Cardim Mendes de Oliveira
May 7, 2003·Cancer·Franco BertoniEric L Staals
Jul 9, 2008·Clinical Orthopaedics and Related Research·Kirk Campbell, Felasfa Wodajo
Apr 3, 2019·Technology in Cancer Research & Treatment·Emanuela PalmeriniGerald Downey
Feb 22, 2012·Virchows Archiv : an International Journal of Pathology·Lihua GongXiaoyuan Huang
Jun 5, 2015·Journal of Neuro-oncology·Huabin YinJianru Xiao
Jun 13, 2015·Oncotarget·Federica MoriSabrina Strano

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