De novo membranoproliferative glomerulonephritis in hepatitis C virus-infected renal allograft recipients

Transplantation
D RothJ Miller

Abstract

Hepatitis C virus (HCV) is the leading cause of non-A, non-B hepatitis among renal allograft recipients. We sought to identify and describe a proteinuric renal disease occurring in our HCV-infected renal transplant patients. Patients with proteinuria exceeding 1 g/day were identified from a cohort of 98 HCV-infected kidney recipients. Qualitative and quantitative reverse transcriptase polymerase chain reaction (RT-PCR) and restriction fragment-length polymorphism of the amplified RT-PCR product was performed to detect circulating HCV RNA, viral titer, and strain type, respectively. An immune complex nephritis (ICN) of the membranoproliferative pattern (MPGN) was found on five of eight biopsies. Two patients infected with the Hutch strain-type developed nephrotic-range proteinuria within three months posttransplant while the remaining three MPGN patients had been transplanted greater than 5 years prior to the onset of proteinuria. Testing for rheumatoid factors, cryoglobulins, hypocomplementemia, and circulating immune complexes failed to show a consistent pattern. Sucrose density gradient (SDG) equilibrium centrifugation was used to determine the buoyant-density of HCV virions from control (HCV-infected nonproteinuric recipient...Continue Reading

Citations

Jan 1, 1996·Journal of Clinical Immunology·K ZuckerJ Miller
Sep 2, 1998·Transplantation Proceedings·J M Morales
Sep 29, 1999·Transplantation Proceedings·J M Morales
Jan 6, 2000·Journal of Hepatology·M P Manns, E G Rambusch
Oct 2, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Catherine M MeyersJay H Hoofnagle
Mar 13, 2003·Kidney International·Sven Arvid Birkeland, Hans H Storm
Mar 23, 2002·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Connie L DavisAlan H Wilkinson
Apr 8, 1998·Current Opinion in Nephrology and Hypertension·J M MoralesJ L Rodicio
Dec 24, 2005·Transplantation·Grégoire BasseLionel Rostaing
Oct 30, 2012·Transplantation·Miguel A Gentil GovantesJosé M Morales
Nov 23, 2012·Transplantation·Marco CarboneJames Neuberger
Sep 28, 2007·Seminars in Dialysis·Fabrizio FabriziPiergiorgio Messa
Jul 12, 2013·Case Reports in Transplantation·Edward J FilipponeJohn L Farber
Jan 1, 2012·Scientifica·Fabrizio Fabrizi
Jul 15, 2015·Expert Opinion on Pharmacotherapy·Fabrizio FabriziFrancesca M Donato
May 24, 2011·International Journal of Nephrology·Ignatius Y S TangEnrico Benedetti
Jul 5, 2013·Kidney International·Fabrizio FabriziPiergiorgio Messa
Sep 14, 2010·Transplantation Proceedings·D G MalufV R Mas
Oct 31, 2008·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Craig E GordonAdeera Levin
Feb 23, 2008·La Presse médicale·Nabil Ben ChaabaneHammouda Saffar
Oct 31, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·F FabriziC Ponticelli
Oct 30, 2012·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Fabrizio FabriziPatrice Cacoub
Aug 15, 2008·Reviews in Medical Virology·Seyed Mohammadmehdi Hosseini MoghaddamNahid Arjmand Kermani
Nov 27, 2007·Liver International : Official Journal of the International Association for the Study of the Liver·Nyingi Kemmer, Guy W Neff
Mar 31, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Marc G GhanyUNKNOWN American Association for the Study of Liver Diseases
Dec 8, 2007·Reviews in Medical Virology·Seema Baid-AgrawalNina Tolkoff-Rubin
Jun 12, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·T HibiG W Burke
Aug 7, 2009·Transplant International : Official Journal of the European Society for Organ Transplantation·Beatriz Domínguez-Gil, Jose M Morales
May 24, 2014·Transplant International : Official Journal of the European Society for Organ Transplantation·Patrizia BurraMarco Senzolo
Apr 28, 2004·Transplantation Proceedings·J M Morales
Sep 19, 2006·Transplantation Proceedings·G BasseL Rostaing
Mar 22, 2006·Transplantation Proceedings·B H OzdemirM Haberal
Nov 25, 2004·Clinics in Liver Disease·R C Dickson
Dec 3, 2014·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Patrice CacoubAnna Linda Zignego
Apr 6, 2016·Clinical and Molecular Hepatology·UNKNOWN Korean Association for the Study of the Liver
Jan 1, 2013·ISRN Nephrology·Fabrizio Fabrizi
Jul 30, 2008·Journal of Hepatology·Paul Martin, Fabrizio Fabrizi

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