De novo synthesis of 1,4-dihydropyridines and pyridines

Journal of the American Chemical Society
Wafa GatiGwilherm Evano

Abstract

An efficient and general method for the synthesis of 1,4-dihydropyridines and pyridines based on a lithiation/isomerization/intramolecular carbolithiation sequence is reported. This procedure provides an efficient, divergent, and straightforward entry to a wide range of polysubstituted dihydropyridines and pyridines starting from readily available N-allyl-ynamides.

References

Apr 6, 2006·Journal of the American Chemical Society·Mohammad Movassaghi, Matthew D Hill
Aug 1, 2007·Journal of the American Chemical Society·Mohammad MovassaghiOmar K Ahmad
May 10, 2008·Journal of the American Chemical Society·Songbai Liu, Lanny S Liebeskind
Apr 1, 2010·Angewandte Chemie·Gwilherm EvanoKévin Jouvin
Sep 29, 2011·Journal of the American Chemical Society·Timothy J DonohoeLuiz C A Barbosa
Nov 23, 2011·Journal of the American Chemical Society·Ming Z Chen, Glenn C Micalizio

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Citations

Oct 30, 2013·Accounts of Chemical Research·Xiao-Na WangRichard P Hsung
Dec 19, 2012·Journal of the American Chemical Society·Jamie M Neely, Tomislav Rovis
Jun 2, 2015·The Journal of Organic Chemistry·Jinhai ShenXiuling Cui
Sep 23, 2016·Angewandte Chemie·Michael MeanwellRobert Britton
Oct 10, 2013·Angewandte Chemie·Daniel G StarkAndrew D Smith
Jul 22, 2014·Chemistry : a European Journal·Rudy LhermetJacques Maddaluno
May 27, 2017·Beilstein Journal of Organic Chemistry·Yan ChenYou Yang
Mar 31, 2015·Chemistry : a European Journal·Rudy LhermetJacques Maddaluno
May 10, 2017·Organic & Biomolecular Chemistry·Cédric TheunissenGwilherm Evano
Jun 22, 2013·Angewandte Chemie·Zugui Shi, Teck-Peng Loh
Nov 8, 2020·Nature Communications·Linwei ZengSunliang Cui
Feb 4, 2021·The Journal of Organic Chemistry·Xiao-Di NieGuo-Qiang Lin
Jun 17, 2014·Journal of the American Chemical Society·Cédric TheunissenGwilherm Evano
Sep 8, 2012·Organic Letters·Donna L SmithHon Wai Lam
Jun 6, 2013·Organic Letters·Wafa GatiGwilherm Evano

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