De-novo thrombolysis for recurrent stroke in a patient with prior history of thrombolysis

Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis
Ethem Murat Arsava, Mehmet Akif Topcuoglu

Abstract

A 67-year-old male with prior history of atrial fibrillation was admitted to our center with acute onset of aphasia. He was treated by intravenous thrombolysis. Approximately 2 years later he presented with left-sided weakness, and was again treated with intravenous tissue plasminogen activator (iv-tPA). The patient responded favorably to thrombolytics on both occasions, without significant complications and with satisfactory recovery. Although there is no apparent reason to withhold thrombolysis in stroke patients with prior history of iv-tPA treatment, experience regarding the use of repeated thrombolysis in recurrent stroke is under-reported in the literature. This study, although reflecting experience from a single case, highlights that repeated administration of iv-tPA is well tolerated in stroke patients with late recurrences and previous history of thrombolysis.

References

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Citations

Nov 30, 2012·Journal of Biomedicine & Biotechnology·Nadia HedhliKatherine A Hajjar
Aug 12, 2014·Journal of the Neurological Sciences·Manuel CappellariPaolo Bovi
Jan 8, 2014·Journal of Stroke·Han Soo YooHyo Suk Nam
Aug 23, 2016·Expert Opinion on Biological Therapy·Aldo BonaventuraFranco Dallegri
Dec 24, 2015·Stroke; a Journal of Cerebral Circulation·Bart M DemaerschalkUNKNOWN American Heart Association Stroke Council and Council on Epidemiology and Prevention
Feb 13, 2018·Neurology. Clinical Practice·Felipe De Los Rios La RosaBrian Wolf

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