De novo tumors after liver transplantation: a single-institution experience

Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Edmund Q SanchezG B Klintmalm

Abstract

The aims of this analysis are to characterize the incidence and types of malignancies and tumor-specific mortality in our institution. Retransplantation, rejection episodes, and OKT3 use were evaluated. Our single-institution prospective database of 1,570 liver transplantations in 1,421 patients was analyzed. Data were statistically analyzed regarding sex, age at transplantation, time from transplantation to diagnosis of tumor, tumor type, and follow-up time. One hundred twenty-five patients (8.8%) developed de novo tumors; 69 patients were men, 56 patients were women. Seventeen patients received more than one allograft. De novo tumors were as follows: skin, 41; lymphomas, 35; lung, 11; colon, 6; anal, 2; rectal, 1; breast, 7; thyroid, 3; oropharyngeal squamous cell, 3; metastatic without primary tumor identified, 4; renal cell, 3; Kaposi's sarcoma, 1; angiosarcoma, 1; uterine, 1; ovarian, 1; pituitary, 1; pancreatic, 2; cholangiocarcinoma, 1; and esophageal, 1. These tumors developed in a statistically significant chronological sequence. Lung cancers and lymphomas showed shorter mean survival times, as well as greater mortality. OKT3 use and rejection did not show significance in tumor development. De novo tumors post-liver tr...Continue Reading

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Citations

Feb 4, 2005·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·J Ignacio HerreroJesús Prieto
Sep 13, 2006·Digestive Diseases and Sciences·Anca CroitoruM Isabel Fiel
Dec 14, 2005·Current Treatment Options in Oncology·Yanis Bellil, Martin J Edelman
Oct 15, 2011·Current Infectious Disease Reports·Cornelius J Clancy, M Hong Nguyen
Jul 16, 2013·Current Oncology Reports·Vinod Ravi, Shreyaskumar Patel
Sep 27, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ulrich BienzlePeter Neuhaus
Jun 29, 2002·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Surasak LeelaudomlipiMasatoshi Makuuchi
Oct 4, 2002·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Michael Charlton
Apr 25, 2003·The New England Journal of Medicine·Sylvie EuvrardAlain Claudy
May 15, 2012·Japanese Journal of Clinical Oncology·Shinsuke KazamaJoji Kitayama
Apr 16, 2004·Transplantation·Jason R StanglRobert Striker
Oct 14, 2004·Transplantation·Michael P Curry
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Jul 2, 2010·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Aniket VadnerkarCornelius J Clancy
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Jul 4, 2007·Clinics in Liver Disease·Lawrence U Liu, Thomas D Schiano
Oct 21, 2005·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Ryoko HondaTakashi Kanematsu
Jul 1, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·B M McGuireUNKNOWN American Society of Transplantation
Aug 12, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Armin FinkenstedtWolfgang Vogel
Mar 17, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Salvador BenllochJoaquín Berenguer

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