De Novo Urologic Malignancies in Renal Transplant Recipients

Transplantation Proceedings
H AntunesA Figueiredo

Abstract

Immunosuppressed organ transplant patients have an elevated risk of malignancies. The aim of this study was to determine the incidence of urologic malignancies in renal transplant recipients, as well as to evaluate their monitoring, treatment, and outcomes. We conducted a retrospective single-center study of 2897 renal transplants between January 1987 and December 2016. Recipients presenting with de novo urologic malignancies were evaluated. We retrospectively assessed the stage of the disease, treatment performed, and subsequent oncologic outcome. Patients with a history of preexisting cancers were excluded. Sixty-one de novo urologic malignancies were recorded in 58 patients. The overall incidence of urologic malignancies was 2.2%. We identified 29 cases of prostate cancer, 23 of renal cell carcinoma, 6 of transitional cell carcinoma of the bladder, and 1 case of penile carcinoma. No cases of testicular tumors were found. The mean age at tumor diagnosis was 58.7 ± 10.1 years. The median time between renal transplantation and tumor development was 84 months (range, 2-310 months). Fifty-six (96.6%) patients received deceased donor kidneys. The overall survival rate at 5 years after diagnosis of urologic tumor was 82.8%. Tumor-r...Continue Reading

References

Jun 30, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·H M RamsayP N Harden
Jan 28, 2003·Transplantation·Luc CormierLaurent Salomon
Apr 28, 2004·Transplantation Proceedings·M VerouxP Veroux
May 22, 2004·Journal of the American Society of Nephrology : JASN·Christian MorathMartin Zeier
Feb 1, 2005·BJU International·Jason HafronArnold Melman
Oct 8, 2005·Transplantation·Nicolas A Muruve, Daniel A Shoskes
Jun 27, 2006·Transplantation Proceedings·M J RibalA Alcaraz
Dec 21, 2006·JAMA : the Journal of the American Medical Association·Claire M VajdicAndrew E Grulich
Jun 19, 2007·Urology·Yao-Min HungJui-Chen Chang
Aug 3, 2007·BJU International·Dler Besarani, David Cranston
Feb 20, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·François KleinclaussUNKNOWN Renal Transplantation Committee of the French Urological Association (AFU)
Mar 20, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Aaron Dall, Sundaram Hariharan
Dec 2, 2008·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·X TillouJ Petit
Sep 22, 2009·Transplantation Proceedings·B EinollahiH Tayebi Khosroshahi
Jul 21, 2010·Current Opinion in Urology·Hervé WallerandJean-Marie Ferrière
Jun 6, 2012·Transplantation Proceedings·M KarczewskiJ Karczewski
Feb 1, 2013·American Journal of Nephrology·Ludovic ViartXavier Tillou
Feb 11, 2014·Transplantation Proceedings·V HeviaF J Burgos
Jul 6, 2014·Actas urologicas españolas·O Rodríguez FabaH Villavicencio
Dec 25, 2015·Journal of the American Society of Nephrology : JASN·Gerardo A VitielloNicole Turgeon

❮ Previous
Next ❯

Citations

Apr 3, 2020·Current Opinion in Urology·Benjamin PradereReza Sari Motlagh
Jul 9, 2021·Transplantation Reviews·Jacopo RomagnoliUNKNOWN Consensus Conference Expert Panel
Oct 14, 2021·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Robert A KeenanNicholas Hegarty
Dec 17, 2021·Current Urology Reports·Cristian Axel Hernández-GaytánAna María Autrán-Gómez

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Sanjiv SaigalJohn O'Grady
Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation
M KarczewskiJ Karczewski
© 2022 Meta ULC. All rights reserved