De subitaneis mortibus. XV. Hereditary stenosis of the His bundle in Pug dogs.

Circulation
T N JamesC E Branch

Abstract

Syncope and sudden death occurs in certain purebred Pug dogs which have been found to have intermittent sinus pauses and paroxysmal second degree heart block on electrocardiographic (ECG) study. We have established a colony of such dogs to study this problem and here report the results of histological examination of the cardiac conduction system in twenty-one of them. These include a dam which may be considered the proband, three of her offspring (two littermates) and three fetal pups in an unborn litter of one of these; three of the four adult dogs died suddenly and unexpectedly. Two groups of puppies descendants of these lines were also studied after they all died within three days of birth. The first group of puppies (8) did not have suitable ECG studies but the second group (6) did and showed ECG changes similar to those in the adult dogs. In all 21 dogs the sinus node was anatomically normal, but in every one there was significant stenosis of the midportion of the His bundle. There was no abnormality of the atrioventricular (A-V) node or of the bundle branches, and the cardiac valves and coronary arteries were normal. Two pups had ventricular septal defects and one of these had an atrial defect as well. All the dogs were o...Continue Reading

References

Aug 1, 1973·American Heart Journal·F UrthalerT N James
Feb 1, 1970·The American Journal of Cardiology·T N James
Jan 1, 1968·Cardiovascular Research·F A RobergeT N James
Apr 1, 1968·Annals of Internal Medicine·T N James, E H Drake
Oct 1, 1968·The American Journal of Cardiology·T N James
May 1, 1967·The American Journal of Cardiology·T N James
Jan 1, 1964·The Anatomical Record·T N JAMES
Jul 1, 1962·The Anatomical Record·T N JAMES

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Citations

Sep 1, 1982·The American Journal of Cardiology·H B Taussig
Sep 11, 1976·British Medical Journal·D P SouthallA M Johnson
Jan 1, 1993·Transactions of the American Clinical and Climatological Association·T N James
Mar 5, 2013·Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology·James W Buchanan
Jan 1, 1988·Annals of the New York Academy of Sciences·S Y Ho, R H Anderson
Mar 29, 2001·The Veterinary Record·A Moneva-JordanJ D Bonagura

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