Deactivation of endothelium and reduction in angiogenesis in psoriatic skin and synovium by low dose infliximab therapy in combination with stable methotrexate therapy: a prospective single-centre study

Arthritis Research & Therapy
Amber Y GoedkoopP P Tak

Abstract

Psoriasis and psoriatic arthritis are inflammatory diseases that respond well to anti-tumour necrosis factor-alpha therapy. To evaluate the effects of anti-tumour necrosis factor-alpha treatment on expression of adhesion molecules and angiogenesis in psoriatic lesional skin and synovial tissue, we performed a prospective single-centre study with infliximab therapy combined with stable methotrexate therapy. Eleven patients with both active psoriasis and psoriatic arthritis received infusions of infliximab (3 mg/kg) at baseline, and at weeks 2, 6, 14 and 22 in an open-label study. In addition, patients continued to receive stable methotrexate therapy in dosages ranging from 5 to 20 mg/week. Clinical assessments, including Psoriasis Area and Severity Index (PASI) and Disease Activity Score (DAS), were performed at baseline and every 2 weeks afterward. In addition, skin biopsies from a target psoriatic plaque and synovial tissue biopsies from a target joint were taken before treatment and at week 4. Immunohistochemical analysis was performed to detect the number of blood vessels, the expression of adhesion molecules and the presence of vascular growth factors. Stained sections were evaluated by digital image analysis. At week 16, t...Continue Reading

References

Aug 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M Fràter-SchröderP Böhlen
Feb 1, 1980·Arthritis and Rheumatism·J F FriesH R Holman
Jan 1, 1994·Archives of Dermatological Research·O J de BoerP K Das
Apr 1, 1994·Archives of Dermatology·C E Griffiths
Jun 1, 1997·The British Journal of Dermatology·D CreamerJ N Barker
Jul 29, 1998·Archives of Dermatological Research·S TerajimaM Kawashima
May 6, 1999·The New England Journal of Medicine·D H PresentS J van Deventer
Nov 30, 2000·The New England Journal of Medicine·P E LipskyUNKNOWN Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study Group
Oct 11, 2001·Arthritis and Rheumatism·A FraserD J Veale
Feb 22, 2002·Medicinal Research Reviews·Helena Yusuf-MakagiansarTeruna J Siahaan
Jun 6, 2002·Journal of the European Academy of Dermatology and Venereology : JEADV·U Wollina, H Konrad
Jan 24, 2003·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·H J NielsenJ K Kristensen
Mar 26, 2003·Clinical and Experimental Immunology·M DrouartE Toussirot
Jun 6, 2003·Journal of the American Academy of Dermatology·Alice B GottliebDaniel G Baker

❮ Previous
Next ❯

Citations

Feb 25, 2011·Annals of the Rheumatic Diseases·M M J HereniusP P Tak
Dec 8, 2010·The Journal of Clinical Investigation·John R ZibertMichael P Schön
Jun 4, 2013·Vascular Cell·Nicola MaruottiDomenico Ribatti
Jan 1, 2009·Clinical and Experimental Gastroenterology·Garrett Lawlor, Alan C Moss
Apr 20, 2005·Current Opinion in Rheumatology·Allen Anandarajah, Christopher T Ritchlin
Apr 20, 2005·Current Opinion in Rheumatology·Peter C Taylor, Bran Sivakumar
Jun 16, 2005·Current Opinion in Rheumatology·Philip J Mease
Jun 10, 2006·Current Opinion in Rheumatology·Barry Bresnihan
Jun 6, 2008·Current Opinion in Rheumatology·Stephen KellyCostantino Pitzalis
Mar 23, 2010·Current Opinion in Rheumatology·Zoltán SzekaneczAlisa E Koch
Aug 13, 2008·Expert Opinion on Therapeutic Targets·Francesca FantuzziGiampiero Girolomoni
Nov 18, 2011·Expert Opinion on Investigational Drugs·A A CrawshawH S Young
Feb 14, 2008·Journal of the European Academy of Dermatology and Venereology : JEADV·S BaumI Bank
Jul 30, 2010·The Journal of Dermatological Treatment·Meaghan DalyApril W Armstrong
Aug 2, 2012·Ultrastructural Pathology·Li Yun ZhangH Ralph Schumacher
Mar 21, 2006·Vascular Pharmacology·Nilesh M PandyaDev D Santani
Oct 12, 2007·Immunology Letters·Axel J Hueber, Iain B McInnes
Feb 24, 2007·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Benjamin F Chong, Henry K Wong
Oct 4, 2016·Expert Review of Clinical Immunology·Wang Sin Gina TanCostantino Pitzalis
Jun 9, 2005·Best Practice & Research. Clinical Rheumatology·Danielle Gerlag, Paul P Tak
Jun 10, 2006·Gastroenterology·Silvio DaneseClaudio Fiocchi
Jul 17, 2008·Journal of Cutaneous Medicine and Surgery·Shannon B RouthouskaNeil J Korman
Nov 6, 2014·BioResearch Open Access·Raif Eren AyataRoxane Pouliot
Mar 17, 2012·The Journal of Rheumatology·Dimitrios Makrygiannakis, Anca Irinel Catrina
Nov 5, 2014·The Journal of Rheumatology·Maria Laura Acosta FelquerPhilip J Mease
May 27, 2006·Arthritis and Rheumatism·Elli KruithofUNKNOWN OMERACT Special Interest Group on Synovial Analysis in Clinical Trials
Jul 28, 2005·Current Rheumatology Reports·Eric M Ruderman
Jul 28, 2005·Current Rheumatology Reports·Tai Teck LeongDouglas J Veale
Oct 31, 2007·Nature Clinical Practice. Rheumatology·Zoltán Szekanecz, Alisa E Koch
Dec 17, 2008·Dermatologic Therapy·Gianfranco AltomareGino A Vena
Oct 1, 2008·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Jeong Ho LeeYoung Soo Ahn
Jul 17, 2010·The British Journal of Dermatology·G AvramidisA Tosca
Jul 14, 2005·Archives of Dermatological Research·Amber Y GoedkoopMaarten C Kraan
Oct 27, 2010·Annals of the New York Academy of Sciences·J Steven AlexanderMoheb Boktor
Jun 9, 2009·Clinical Rheumatology·Concepción MollJuan D Cañete
Nov 8, 2013·European Journal of Clinical Pharmacology·Nicola MaruottiDomenico Ribatti

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsies
biopsy

Software Mentioned

Leica
Qwin
SPSS
Syndia

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.