Deactivation of the parahippocampal gyrus preceding auditory hallucinations in schizophrenia

The American Journal of Psychiatry
Kelly M J DiederenIris E C Sommer

Abstract

Activation in a network of language-related regions has been reported during auditory verbal hallucinations. It remains unclear, however, how this activation is triggered. Identifying brain regions that show significant signal changes preceding auditory hallucinations might reveal the origin of these hallucinations. Twenty-four patients with a psychotic disorder indicated the presence of auditory verbal hallucinations during 3-Tesla functional magnetic resonance imaging by squeezing a handheld balloon. A one-sample t test was performed to reveal groupwise activation during hallucinations. To enable analysis of brain activation 6 to 0 seconds preceding hallucinations, a tailored 'selective averaging' method, without any a priori assumptions concerning the hemodynamic response profile, was performed. To control for motor-related activation, 15 healthy comparison subjects squeezed a balloon at matched time intervals. Groupwise analysis during auditory verbal hallucinations revealed brain activation in bilateral (right more than left) language-related regions and bilateral motor regions. Prominent deactivation preceding these hallucinations was observed in the left parahippocampal gyrus. In addition, significant deactivation preced...Continue Reading

Citations

Jun 22, 2012·Psychological Medicine·K DaalmanIris E C Sommer
Dec 4, 2012·Psychological Medicine·K M J DiederenI E C Sommer
Apr 20, 2011·Proceedings of the National Academy of Sciences of the United States of America·Dirk De RidderBerthold Langguth
Nov 26, 2010·Brain : a Journal of Neurology·Kelly M J DiederenIris E C Sommer
Apr 27, 2012·Cerebral Cortex·Renaud JardriDelphine Pins
Apr 30, 2011·Schizophrenia Bulletin·Kelly M J DiederenIris E C Sommer
Oct 27, 2010·Current Opinion in Neurology·Johanna C GollJason D Warren
Oct 15, 2011·PloS One·Dirk De RidderMarco Congedo
Sep 13, 2012·PloS One·Iris E SommerSimon B Eickhoff
Sep 17, 2013·PloS One·Alexander M RappMichael Erb
Jan 15, 2014·PloS One·Guillermo HorgaEduard Parellada
Jul 28, 2011·Journal of Psychiatry & Neuroscience : JPN·Nadine Donata WolfRobert Christian Wolf
Dec 3, 2014·Psychiatry Research·Antoin D de WeijerEduard H J F Boezeman
Oct 6, 2011·The British Journal of Psychiatry : the Journal of Mental Science·Ralph E HoffmanMichelle Hampson
Feb 3, 2016·Frontiers in Neuroscience·Peter MoseleyCharles Fernyhough
Jan 8, 2016·Cognitive Neuropsychiatry·Mohamad El HajPascal Antoine
Oct 19, 2010·Consciousness and Cognition·Hans J Markowitsch, Angelica Staniloiu
Dec 3, 2010·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·J KindlerT Koenig
Aug 19, 2011·The European Journal of Neuroscience·Sven VannesteDirk De Ridder
Oct 25, 2011·Human Brain Mapping·Martin SchecklmannBerthold Langguth
Mar 27, 2016·Human Brain Mapping·Stéphanie LefebvreRenaud Jardri
Jun 7, 2011·Psychoneuroendocrinology·Royce J LeeAlan Klock
Jun 5, 2013·NeuroImage·Sven VannesteDirk De Ridder
Mar 11, 2015·International Journal of Neural Systems·Darya ChyzhykAnn K Shinn
Jun 25, 2015·Frontiers in Neurology·Dirk De RidderRodolfo Llinas
Nov 8, 2014·NeuroImage. Clinical·Maria de la Iglesia-VayaJulio Sanjuan
Mar 23, 2015·Biological Psychology·Frank ScharnowskiNikolaus Weiskopf
Mar 8, 2013·Schizophrenia Research·K M J DiederenI E C Sommer

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Software Mentioned

Automatic Anatomical Labeling Atlas
SPM2
Statistical Parametric Mapping ( SPM2

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