Deadlock, a novel protein of Drosophila, is required for germline maintenance, fusome morphogenesis and axial patterning in oogenesis and associates with centrosomes in the early embryo.

Developmental Biology
Kristina WehrTrudi Schüpbach

Abstract

The deadlock gene is required for a number of key developmental events in Drosophila oogenesis. Females homozygous for mutations in the deadlock gene lay few eggs and those exhibit severe patterning defects along both the anterior-posterior and dorsal-ventral axis. In this study, we analyzed eggs and ovaries from deadlock mutants and determined that deadlock is required for germline maintenance, stability of mitotic spindles, localization of patterning determinants, oocyte growth and fusome biogenesis in males and females. Deadlock encodes a novel protein which colocalizes with the oocyte nucleus at midstages of oogenesis and with the centrosomes of early embryos. Our genetic and immunohistological experiments point to a role for Deadlock in microtubule function during oogenesis.

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Citations

Jun 5, 2007·Genome Génome / Conseil National De Recherches Canada·Sylvia Glen LevinePaul Lasko
Mar 22, 2008·Developmental Biology·Daniel V LighthouseAllan C Spradling
Jan 18, 2015·Developmental Biology·Aidan P Maartens, Nicholas H Brown
Mar 4, 2014·Differentiation; Research in Biological Diversity·James Nicholas HughesJoy Rathjen
Jun 12, 2013·Developmental Biology·Markus TögelAchim Paululat
Apr 9, 2019·Open Biology·Swapnil S Parhad, William E Theurkauf
Mar 3, 2020·Frontiers in Cell and Developmental Biology·Taylor D HinnantElizabeth T Ables
Nov 1, 2021·Genetics·Mostafa F ElMaghrabyJulius Brennecke

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