Deadly conversations: nuclear-mitochondrial cross-talk

Journal of Bioenergetics and Biomembranes
Valina L Dawson, Ted M Dawson

Abstract

Neuronal damage following stroke or neurodegenerative diseases is thought to stem in part from overexcitation of N -methyl-D-aspartate (NMDA) receptors by glutamate. NMDA receptors triggered neurotoxicity is mediated in large part by activation of neuronal nitric oxide synthase (nNOS) and production of nitric oxide (NO). Simultaneous production of superoxide anion in mitochondria provides a permissive environment for the formation of peroxynitrite (ONOO-). Peroxynitrite damages DNA leading to strand breaks and activation of poly(ADP-ribose) polymerase-1 (PARP-1). This signal cascade plays a key role in NMDA excitotoxicity, and experimental models of stroke and Parkinson's disease. The mechanisms of PARP-1-mediated neuronal death are just being revealed. While decrements in ATP and NAD are readily observed following PARP activation, it is not yet clear whether loss of ATP and NAD contribute to the neuronal death cascade or are simply a biochemical marker for PARP-1 activation. Apoptosis-inducing factor (AIF) is normally localized to mitochondria but following PARP-1 activation, AIF translocates to the nucleus triggering chromatin condensation, DNA fragmentation and nuclear shrinkage. Additionally, phosphatidylserine is exposed a...Continue Reading

Citations

Mar 24, 2006·Apoptosis : an International Journal on Programmed Cell Death·L XiD Ma
May 16, 2013·Apoptosis : an International Journal on Programmed Cell Death·Chloé LeprêtreAlicia Torriglia
Dec 28, 2006·Neurochemical Research·Sibel Kahraman, Gary Fiskum
Mar 21, 2012·Molecular Neurobiology·Joanna B StrosznajderRobert P Strosznajder
Jun 1, 2005·Free Radical Biology & Medicine·J RodrigoA Martínez
Jun 7, 2008·Cell Death and Differentiation·S LandshamerC Culmsee
Aug 2, 2007·Nature Reviews. Drug Discovery·Csaba SzabóRafael Radi
May 23, 2008·Proceedings of the National Academy of Sciences of the United States of America·Shuzhen GuoEng H Lo
Mar 9, 2011·Proceedings of the National Academy of Sciences of the United States of America·Sanjay C KeswaniAhmet Höke
Jan 16, 2013·Proceedings of the National Academy of Sciences of the United States of America·Mira SastriSusan S Taylor
Oct 13, 2006·Antioxidants & Redox Signaling·Susan E Browne, M Flint Beal
Sep 9, 2006·Microbiology and Molecular Biology Reviews : MMBR·Paul O HassaMichael O Hottiger
Jan 24, 2007·Physiological Reviews·Pál PacherLucas Liaudet
Apr 23, 2008·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Eugene ParkAndrew J Baker
Sep 28, 2010·Yi chuan = Hereditas·Lian-Bang WangChun-Hua Shan
Dec 11, 2013·Translational Stroke Research·Katrina OwensTibor Kristian
Apr 24, 2012·Expert Opinion on Investigational Drugs·Renu A KowluruJulia M Santos
Jan 11, 2016·Histochemistry and Cell Biology·Maddalena GrimaldiMaria Grazia Bottone
Feb 12, 2011·Journal of Photochemistry and Photobiology. B, Biology·Yun-Mi JeongDong-Seok Kim
Apr 7, 2009·Free Radical Biology & Medicine·Renu A Kowluru, Mamta Kanwar
Apr 1, 2009·Experimental Neurology·Yingfei WangTed M Dawson
May 21, 2008·Brain & Development·Michael V JohnstonMasahiro Tsuji
Mar 12, 2016·Free Radical Biology & Medicine·Attila BrunyanszkiCsaba Szabo
May 2, 2008·European Journal of Pharmacology·Amos A FatokunRobert A Smith
Jan 15, 2008·Free Radical Biology & Medicine·Joan VillenaAndrew F G Quest
Apr 24, 2007·Biochemical and Biophysical Research Communications·Tiago Fleming OuteiroAleksey G Kazantsev
Dec 21, 2006·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ester VerdaguerAntoni Camins
Sep 2, 2008·Biochemical Pharmacology·Alicia TorrigliaElisabeth Martin
Jul 16, 2015·Journal of Cellular Physiology·Concetta Paola IlissoMarina Porcelli
Aug 23, 2008·Alcoholism, Clinical and Experimental Research·Priscilla P CherianGeorge I Henderson
Feb 13, 2009·British Journal of Pharmacology·Csaba Szabo
Aug 29, 2012·Movement Disorders : Official Journal of the Movement Disorder Society·Paolo CalabresiTed M Dawson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptotic Caspases

Apoptotic caspases belong to the protease enzyme family and are known to play an essential role in inflammation and programmed cell death. Here is the latest research.

Bacterial Respiration

This feed focuses on cellular respiration in bacteria, known as bacterial respiration. Discover the latest research here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
Seong-Woon YuValina L Dawson
Cellular and Molecular Life Sciences : CMLS
D W KohValina L Dawson
© 2021 Meta ULC. All rights reserved