PMID: 6988923Jan 1, 1980Paper

Deafferentation and causalgia

Research Publications - Association for Research in Nervous and Mental Disease
R R TaskerP Hawrylyshyn

Abstract

The concept of deafferentation pain has been developed as an entity distinct from somatic pain which can arise in the course of both cancerous and nonmalignant disease. Its distinctive clinical features and responses to diagnostic and therapeutic manipulations have been reviewed. Evidence is marshalled to show that it results from gradually developing alterations in the central nervous system, which, once established, persist despite removal of the original stimulus. Evidence is presented that the mesencephalic tegmentum may be part of a reticulothalamocortical system undergoing denervation hypersensitivity following deafferentation, whose stimulation by electric impulses, and, presumably, naturally occurring neural inputs, can result in a painful conscious experience reproducing the patient's pain in a manner similar to that whereby stimulation of temporal-parietal association cortex elicits recall of past events.

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

Current Rheumatology Reports
Martin Lotze, G L Moseley
Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association
Takashi Hanakawa
Nederlands tijdschrift voor tandheelkunde
R J BunW J Meyler
© 2021 Meta ULC. All rights reserved