Deafferentation-induced alterations in mitral cell dendritic morphology in the adult zebrafish olfactory bulb

Journal of Bioenergetics and Biomembranes
Joanna M PozzutoChristine A Byrd-Jacobs

Abstract

The removal of afferent input to the olfactory bulb by both cautery and chemical olfactory organ ablation in adult zebrafish results in a significant decrease in volume of the ipsilateral olfactory bulb. To examine the effects of deafferentation at a cellular level, primary output neurons of the olfactory bulb, the mitral cells, were investigated using retrograde tract tracing with fluorescent dextran using ex vivo brain cultures. Morphological characteristics including the number of major dendritic branches, total length of dendritic branches, area of the dendritic arbor, overall dendritic complexity, and optical density of the arbor were used to determine the effects of deafferentation on mitral cell dendrites. Following 8 weeks of permanent deafferentation there were significant reductions in the total length of dendritic branches, the area of the dendritic arbor, and the density of fine processes in the dendritic tuft. With 8 weeks of chronic, partial deafferentation there were significant reductions in all parameters examined, including a modified Sholl analysis that showed significant decreases in overall dendritic complexity. These results show the plasticity of mitral cell dendritic structures in the adult brain and pro...Continue Reading

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Citations

Apr 21, 2020·PLoS Biology·Florence KermenEmre Yaksi
Apr 17, 2019·International Journal of Molecular Sciences·Erika Calvo-Ochoa, Christine A Byrd-Jacobs
Oct 28, 2019·IBRO Reports·Susanna R Var, Christine A Byrd-Jacobs

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