PMID: 11337195May 5, 2001Paper

Deafferentation of the septo-hippocampal pathway in rats as a model of the metabolic events in Alzheimer's disease

International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience
U KrügelM Bigl

Abstract

Changes in the metabolic activity within the brain of patients suffering from Alzheimer's disease (AD) were investigated and compared with biochemical alterations in the hippocampus induced by fimbria/fornix transection in the rat. The deafferentation of the hippocampus results in a degeneration of cholinergic septo-hippocampal terminals accompanied by a persistent decrease of choline acetyltransferase (ChAT) and acetylcholine esterase (AChE) activities similar to the cholinergic malfunction in AD. In the animal model the [3H]-cytochalasin B binding to the glucose transporters was elevated up to the day 7 after surgery as was the activity of the phosphofructokinase (PFK) on day 3. A reactive astrogliosis could be evidenced by the upregulation of glial fibrillary acidic protein (GFAP). An increase of the PFK activity was also found in AD being accompanied by enhanced level of GFAP as well. A higher concentration of mRNA for all three isoenzymes of PFK was shown by reverse transcription (RT)-real time polymerase chain reaction (PCR) amplification. However, the pattern of PFK isoenzyme proteins and mRNAs did neither change in diseased human nor in the lesioned rat brain. The activities of the mitochondrial enzymes pyruvate dehydro...Continue Reading

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Citations

Oct 3, 2003·Neurobiology of Learning and Memory·Paul E Gold
Sep 17, 2002·Molecular Aspects of Medicine·Vitaliy B Borisov
May 5, 2001·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·R Schliebs
Aug 9, 2013·Neurochemical Research·Francesca GelfoLaura Mandolesi
Jul 7, 2007·Neurobiology of Learning and Memory·Barbara B OswaldDonald A Powell
Apr 27, 2005·Annals of Neurology·Parvesh BubberGary E Gibson
Jan 5, 2018·Proceedings. Biological Sciences·Michael I CoatesPatrick J La Riviere
Nov 14, 2007·Expert Review of Neurotherapeutics·John Xi Chen, Shi Du Yan

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