PMID: 5917091Oct 21, 1966

Dealkylation and loss of capacity for reactivation of cholinesterase inhibited by sarin

L W HarrisW J Cliff


Inhibition of rat brain acetylcholinesterase by (32)P-sarin in vivo results initially in (32)P-isopropylmethylphosphonylated enzyme. The percentage of inhibited enzyme that could not be reactivated by pyridinium aldoxime methochloride (aged enzyme) approximated the amount of radioactivity identified as (32)P-methylphosphonate. The (32)P-isopropyl methylphosphonate not released fromthe inhibited enzyme by the oxime accounted for 51 +/- 10 percent ( standard deviation) of the radioactivity fixed to brain tissue. It showed no correlation with aging and was probably bound to sites other than acetylcholinesterase.


Jul 24, 1981·Biochimica Et Biophysica Acta·K W Lanks, M J Seleznick
Nov 1, 1981·Biochemical Pharmacology·G BeauregardB D Roufogalis
Feb 1, 1974·Toxicology and Applied Pharmacology·F R Sidell, W A Groff
Sep 8, 2012·The Journal of Pharmacology and Experimental Therapeutics·Jun ZhangJohn R Cashman
Nov 26, 2008·Neurotoxicology and Teratology·Raymond F GenoveseE Michael Jakubowski
Mar 1, 2012·Drug Testing and Analysis·Melinda E Wales, Tony E Reeves
Aug 1, 1974·Biochemical Pharmacology·L W HarrisR D Moore
Dec 17, 2009·Archives of Biochemistry and Biophysics·Patrick Masson, Oksana Lockridge
Jan 1, 1970·Toxicology and Applied Pharmacology·E F MurthaT A Innerebner
Mar 27, 2010·Chemico-biological Interactions·Patrick MassonOksana Lockridge
May 4, 2016·Proceedings of the National Academy of Sciences of the United States of America·Anders AllgardssonF J Ekström
Dec 15, 1982·Biochemical Pharmacology·M Y Osman
Jun 18, 2016·Toxicology·Iris MangasTanos Celmar Costa França
Aug 19, 2007·Toxicological Sciences : an Official Journal of the Society of Toxicology·He LiOksana Lockridge
Jul 19, 2003·The Journal of Biological Chemistry·Yvain NicoletFlorian Nachon

Related Concepts

Brain Chemistry
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