PMID: 5917091Oct 21, 1966

Dealkylation and loss of capacity for reactivation of cholinesterase inhibited by sarin

Science
L W HarrisW J Cliff

Abstract

Inhibition of rat brain acetylcholinesterase by (32)P-sarin in vivo results initially in (32)P-isopropylmethylphosphonylated enzyme. The percentage of inhibited enzyme that could not be reactivated by pyridinium aldoxime methochloride (aged enzyme) approximated the amount of radioactivity identified as (32)P-methylphosphonate. The (32)P-isopropyl methylphosphonate not released fromthe inhibited enzyme by the oxime accounted for 51 +/- 10 percent ( standard deviation) of the radioactivity fixed to brain tissue. It showed no correlation with aging and was probably bound to sites other than acetylcholinesterase.

Citations

Jul 24, 1981·Biochimica Et Biophysica Acta·K W Lanks, M J Seleznick
Nov 1, 1981·Biochemical Pharmacology·G BeauregardB D Roufogalis
Feb 1, 1974·Toxicology and Applied Pharmacology·F R Sidell, W A Groff
Sep 8, 2012·The Journal of Pharmacology and Experimental Therapeutics·Jun ZhangJohn R Cashman
Nov 26, 2008·Neurotoxicology and Teratology·Raymond F GenoveseE Michael Jakubowski
Mar 1, 2012·Drug Testing and Analysis·Melinda E Wales, Tony E Reeves
Aug 1, 1974·Biochemical Pharmacology·L W HarrisR D Moore
Dec 17, 2009·Archives of Biochemistry and Biophysics·Patrick Masson, Oksana Lockridge
Jan 1, 1970·Toxicology and Applied Pharmacology·E F MurthaT A Innerebner
Mar 27, 2010·Chemico-biological Interactions·Patrick MassonOksana Lockridge
May 4, 2016·Proceedings of the National Academy of Sciences of the United States of America·Anders AllgardssonF J Ekström
Dec 15, 1982·Biochemical Pharmacology·M Y Osman
Jun 18, 2016·Toxicology·Iris MangasTanos Celmar Costa França
Aug 19, 2007·Toxicological Sciences : an Official Journal of the Society of Toxicology·He LiOksana Lockridge
Jul 19, 2003·The Journal of Biological Chemistry·Yvain NicoletFlorian Nachon

Related Concepts

Senility
Brain Chemistry
Cholinesterase Inhibitors, Reversible
Cholase
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