Deamidation of human proteins

Proceedings of the National Academy of Sciences of the United States of America
N E Robinson, A B Robinson

Abstract

Deamidation of asparaginyl and glutaminyl residues causes time-dependent changes in charge and conformation of peptides and proteins. Quantitative and experimentally verified predictive calculations of the deamidation rates of 1,371 asparaginyl residues in a representative collection of 126 human proteins have been performed. These rates suggest that deamidation is a biologically relevant phenomenon in a remarkably large percentage of human proteins.

References

Oct 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·A B Robinson, L R Robinson
Aug 1, 1986·Archives of Biochemistry and Biophysics·K U Yüksel, R W Gracy
Jul 1, 1986·International Journal of Peptide and Protein Research·Y C MeinwaldH A Scheraga
Jan 1, 1974·International Journal of Peptide and Protein Research·A B RobinsonM Legaz
Jan 1, 1974·Current Topics in Cellular Regulation·A B Robinson, C J Rudd
May 1, 1974·Analytical Biochemistry·J W Scotchler, A B Robinson
Jan 1, 1974·International Journal of Peptide and Protein Research·A B Robinson, J W Scotchler
Mar 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·A B Robinson
Nov 28, 1973·Journal of the American Chemical Society·A B RobinsonJ H McKerrow
Jan 11, 1974·Science·J H McKerrow, A B Robinson
Aug 1, 1971·Analytical Biochemistry·J H McKerrow, A B Robinson
Jul 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·A B RobinsonP Cary
Sep 29, 1970·Biochimica Et Biophysica Acta·U J LewisW C Hopkins
Jan 1, 1995·Journal of Pharmaceutical Sciences·D B VolkinC R Middaugh
Oct 1, 1995·Archives of Biochemistry and Biophysics·A Q SunR W Gracy
Oct 1, 1993·Protein Science : a Publication of the Protein Society·S M PotterD W Aswad
Apr 1, 1997·Biochemistry and Molecular Biology International·Z MinicD Vucelic
May 28, 1998·The Journal of Biological Chemistry·H LindnerW Helliger
Nov 24, 1999·The Journal of Peptide Research : Official Journal of the American Peptide Society·S Capasso, S Salvadori
Jun 14, 2000·The Journal of Biological Chemistry·L Takemoto, D Boyle
Feb 7, 2001·Proceedings of the National Academy of Sciences of the United States of America·N E Robinson, A B Robinson
Apr 11, 2001·Proceedings of the National Academy of Sciences of the United States of America·N E Robinson, A B Robinson
Jul 5, 2001·The Journal of Peptide Research : Official Journal of the American Peptide Society·N E RobinsonR B Merrifield

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Citations

Feb 10, 2010·Pharmaceutical Research·Mark Cornell ManningDerrick S Katayama
Mar 18, 2004·Bioorganic & Medicinal Chemistry Letters·Cédrik GarinoJean-Louis Kraus
Sep 18, 2012·Journal of Chromatography. a·Thomas LinkeAlan K Hunter
Nov 21, 2008·Journal of the American Society for Mass Spectrometry·Ning LiuZongwei Cai
Apr 6, 2004·Mechanisms of Ageing and Development·Noah E Robinson, Arthur B Robinson
Jun 24, 2003·Journal of Molecular and Cellular Cardiology·Melanie Y WhiteRichmond W Jeremy
Sep 25, 2002·Journal of Molecular Biology·Miljan Simonovic, Karl Volz
Jun 28, 2012·Journal of the American Chemical Society·Emily B DunkelbergerMartin T Zanni
Feb 9, 2012·Molecular Pharmaceutics·Mary E KrauseJennifer S Laurence
Nov 23, 2011·Journal of Proteome Research·Enrico CappelliniJesper V Olsen
Dec 3, 2013·Journal of Proteome Research·Angelito I NepomucenoDavid C Muddiman
Jun 28, 2012·Nature Communications·Jae-Cheol LeeJeung-Whan Han
Dec 22, 2012·Nature Reviews. Molecular Cell Biology·Brandon H Toyama, Martin W Hetzer
Feb 27, 2003·European Journal of Biochemistry·Therese SolstadTorgeir Flatmark
Apr 29, 2010·The Journal of Biological Chemistry·Michael BidinostiNahum Sonenberg
Apr 27, 2011·The Journal of Biological Chemistry·Quanzhou LuoJette Wypych
Jan 21, 2012·Molecular & Cellular Proteomics : MCP·Mark A BreidenbachCarolyn R Bertozzi
Jul 26, 2011·Molecular & Cellular Proteomics : MCP·Piliang HaoSiu Kwan Sze
Mar 17, 2010·Rejuvenation Research·Roger John Willis Truscott
Dec 5, 2003·European Journal of Biochemistry·Vladimir V RogovHeinz Rüterjans
Apr 14, 2007·BMC Bioinformatics·K MizuguchiM V Cubellis
Feb 7, 2014·The Journal of Physical Chemistry. B·Mohammad A HalimRaymond A Poirier
Oct 31, 2002·Proceedings of the National Academy of Sciences of the United States of America·Shunji TomatsuWilliam S Sly
Apr 18, 2002·Proceedings of the National Academy of Sciences of the United States of America·Noah E Robinson
Jun 20, 2013·Journal of Proteomics·Martin ČernýBřetislav Brzobohatý
Sep 9, 2006·Journal of Pharmaceutical Sciences·Aditya A Wakankar, Ronald T Borchardt
Jan 5, 2016·Structure·Adam M R de GraffKen A Dill
Dec 26, 2015·Proteomics·Maria Lluch-SenarLuis Serrano
Jan 29, 2011·Journal of Proteomics·Angelina TaichribChristian Neusüss

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