Death by Suicide in Graves' Disease and Graves' Orbitopathy: A Nationwide Danish Register Study

Thyroid : Official Journal of the American Thyroid Association
Charlotte Ferløv-SchwensenLaszlo Hegedüs

Abstract

Graves' disease (GD) is associated with excess morbidity and mortality, but little is known about unnatural manners of death and the potential relation with Graves' orbitopathy (GO). This study investigated the risk of unnatural death in Graves' patients with and without orbitopathy compared to matched control populations. This was a cohort study covering all adult Danes (≥18 years) diagnosed with GD or GO during 1995-2012. Median follow-up time was 7.9 years (range 0-17.5 years). Utilizing the Danish Register of Causes of Death and the Danish National Patient Registry, 28,461 subjects with GD and 3965 with GO were identified and matched for age and sex with four subjects from the background population. The manner of death was identified, and hazard ratios (HR) for mortality due to unnatural deaths (accident, suicide, violence/homicide, and unknown) were calculated using Cox regression analyses, adjusted for pre-existing somatic and psychiatric morbidity. In Graves' disease overall (GD + GO), there was an increased risk of death from unknown unnatural manners (HR = 2.01 [confidence interval (CI) 1.17-3.45], p = 0.012) and of suicide, although the latter difference was not with certainty statistically significant (HR = 1.43 [CI ...Continue Reading

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Citations

Jul 18, 2019·Current Opinion in Ophthalmology·Jonathan C P Roos, Rachna Murthy
Sep 3, 2018·Endocrine·Cínthia Minatel RiguettoDenise Engelbrecht Zantut-Wittmann
Jun 1, 2020·Journal of Endocrinological Investigation·P PerrosUNKNOWN European Group on Graves’ Orbitopathy
Feb 14, 2021·The British Journal of Ophthalmology·Shoaib UgradarRaymond Douglas
Jan 5, 2021·Frontiers in Endocrinology·Grigorios Panagiotou, Petros Perros
Aug 5, 2019·American Journal of Ophthalmology·Amy PatelRaymond S Douglas
Apr 6, 2021·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Wen ChenHao Hu

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