Death of a Fetus With Myeloproliferative Disorder and Trisomy 21

The Journal of the American Osteopathic Association
Danielle PrenticeJohn Stanley

Abstract

A 27-year-old woman, gravida 2, para 1, presented at 24 weeks gestation with an intrauterine death. She previously consulted with maternal-fetal medicine because of a high suspicion of trisomy 21 after abnormal maternal serum screen and cell-free DNA test results. The patient elected to have chromosomal analysis following the death of the fetus, which confirmed a trisomy 21 diagnosis. Placental pathologic findings suggested that the cause of fetal death was total occlusion of the major vessels due to the accumulation of myeloid precursor cells, a novel mechanism. This case report discusses the rare finding of myeloproliferative disorder as a cause of death of a fetus with trisomy 21.

References

Oct 1, 1986·Archives of Disease in Childhood·E S GrayJ G Simpson
Jun 2, 2001·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·J M SmrcekU Gembruch
Sep 25, 2017·Obstetrics and Gynecology·UNKNOWN American College of Obstetricians and Gynecologists, UNKNOWN Society for Maternal-Fetal Medicine

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