Death of dopaminergic neurones in the rat substantia nigra can be induced by damage to globus pallidus

The European Journal of Neuroscience
A K WrightG W Arbuthnott

Abstract

Parkinson's disease is a debilitating disorder that results from the death of dopaminergic neurones in the substantia nigra. Subthalamic nucleus neurones use glutamate as their neurotransmitter and send excitatory projections to the substantia nigra. Changes in both the mean firing rate and firing pattern of neurones of the subthalamic nucleus have been found in patients with this disease. This has led to the suggestion that hyperactivity of the subthalamic nucleus may be involved in the pathology of the dopaminergic neurones. Subthalamic nucleus lesions or treatment with glutamatergic antagonists can be neuroprotective in animal models of Parkinson's disease but until now there has been no direct evidence that hyperactivity of subthalamic nucleus neurones can lead to downstream cell death. Here we show that lesions of the rat globus pallidus (a treatment that has been shown to increase subthalamic nucleus neuronal activity) result in a significant reduction of the number of dopaminergic neurones in the substantia nigra.

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Citations

Feb 9, 2012·Neurotoxicology·W Michael CaudleGary W Miller
Nov 22, 2007·Parkinsonism & Related Disorders·Natasha Luquin, John Mitrofanis
Aug 15, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Guglielmo FoffaniJosé A Obeso

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