Death rates in HIV-positive antiretroviral-naive patients with CD4 count greater than 350 cells per microL in Europe and North America: a pooled cohort observational study.

Lancet
Study Group on Death Rates at High CD4 Count in Antiretroviral Naive PatientsAndrew N Phillips

Abstract

Whether people living with HIV who have not received antiretroviral therapy (ART) and have high CD4 cell counts have higher mortality than the general population is unknown. We aimed to examine this by analysis of pooled data from industrialised countries. We merged data on demographics, CD4 cell counts, viral-load measurements, hepatitis C co-infection status, smoking status, date of death, and whether death was AIDS-related or not from 23 European and North American cohorts. We calculated standardised mortality ratios (SMRs) standardised by age, sex, and year, stratifying by risk group. Data were included for patients aged 20-59 years who had at least one CD4 count greater than 350 cells per microL while ART naive. All pre-ART CD4 counts greater than 350 cells per microL from January, 1990, to December, 2004, were included. We investigated mortality for four risk groups--men who have sex with men, heterosexual people, injecting drug users, and those at other or unknown risk. The association between CD4 cell count and death rate was investigated by use of Poisson regression methods. Data were analysed for 40,830 patients contributing 80,682 person-years of follow-up. Of 419 deaths, 401 were used in the SMR analysis: 100 men wh...Continue Reading

References

Sep 19, 2003·Lancet·Christian JaggyUNKNOWN Swiss HIV Cohort Study
Sep 28, 2005·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Ard van SighemUNKNOWN ATHENA National Observational Cohort Study
Aug 16, 2006·Archives of Internal Medicine·Rainer WeberJens D Lundgren
Dec 28, 2006·The Journal of Infectious Diseases·Ann-Brit Eg HansenNiels Obel
Jul 11, 2007·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Charlotte LewdenUNKNOWN Agence Nationale de Recherches sur le Sida et les Hepatites Virales (ANRS) CO3 AQUITAINE Study Group
Aug 11, 2007·AIDS·Andrew N PhillipsUNKNOWN UK Collaborative HIV Cohort Study
May 14, 2008·The Journal of Infectious Diseases·UNKNOWN Strategies for Management of Antiretroviral Therapy (SMART) Study GroupRobin Wood
Jul 3, 2008·JAMA : the Journal of the American Medical Association·Krishnan BhaskaranUNKNOWN CASCADE Collaboration
Aug 5, 2008·JAMA : the Journal of the American Medical Association·Scott M HammerUNKNOWN International AIDS Society-USA
Nov 14, 2008·AIDS·Andrew N PhillipsJens D Lundgren
Apr 3, 2009·The New England Journal of Medicine·Mari M KitahataUNKNOWN NA-ACCORD Investigators
Jan 9, 2010·AIDS·UNKNOWN UK Collaborative HIV Cohort (UK CHIC) Steering CommitteeAndrew N Phillips

❮ Previous
Next ❯

Citations

Feb 11, 2011·Current Infectious Disease Reports·Frank S Rhame
Mar 28, 2013·AIDS Research and Human Retroviruses·Constanza LuceroFelipe García
Apr 12, 2012·International Journal of Epidemiology·UNKNOWN Collaboration of Observational HIV Epidemiological Research Europe (COHERE) in EuroCoordGeneviève Chêne
Nov 14, 2012·International Journal of Epidemiology·Margaret T MayUNKNOWN Antiretroviral Therapy Cohort Collaboration (ART-CC)
May 18, 2012·The Journal of Infectious Diseases·Virginia A Triant
Apr 18, 2013·The Journal of Infectious Diseases·Enwu LiuUNKNOWN China's National Working Group on Methadone Maintenance Treatment
Nov 18, 2011·AIDS·Fumiyo NakagawaAndrew N Phillips
May 24, 2011·Journal of Acquired Immune Deficiency Syndromes : JAIDS·David W DowdyDiane V Havlir
Jun 10, 2011·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Stephen T WrightUNKNOWN Australian HIV Observational Database
Oct 27, 2011·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Charlotte LewdenUNKNOWN ANRS 12222 MorbidityMortality Study Group
May 18, 2012·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Robert C KaplanRussell P Tracy
May 2, 2012·Clinical Trials : Journal of the Society for Clinical Trials·Abdel G BabikerUNKNOWN INSIGHT START Study Group
Jan 20, 2011·AIDS Research and Therapy·Alan R LifsonUNKNOWN Infectious Disease Clinical Research Program (IDCRP) HIV Working Group
May 30, 2014·PloS One·Alison J RodgerUNKNOWN ASTRA (Antiretrovirals, Sexual Transmission Risk and Attitudes) Study Group
Jan 21, 2014·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Giovanni GuaraldiAntonella Dʼarminio Monforte
Sep 22, 2012·Der Internist·M StöckleM Battegay
Dec 12, 2012·Current Opinion in Infectious Diseases·Fumiyo NakagawaAndrew Phillips
Jul 20, 2010·Lancet·Ingrid V Bassett, Paul E Sax
Sep 13, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Maunank ShahDavid W Dowdy
Mar 11, 2016·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·Claudia MichalikNorbert H Brockmeyer
Jul 19, 2012·Scandinavian Journal of Infectious Diseases·Kristina ThorsteinssonAnne-Mette Lebech
Apr 4, 2013·Scandinavian Journal of Infectious Diseases·Josep M LlibreBonaventura Clotet
May 29, 2012·Human Vaccines & Immunotherapeutics·Felipe GarcíaTeresa Gallart
Apr 9, 2013·Revista Da Sociedade Brasileira De Medicina Tropical·Maria Angelina da Silva ZuqueCarlos Magno Castelo Branco Fortaleza
Feb 5, 2014·Journal of the International Association of Providers of AIDS Care·Ellen M TedaldiUNKNOWN HOPS Investigators
Mar 10, 2017·Virulence·Marco RipaGiuseppe Tambussi
Oct 6, 2015·Journal of the International AIDS Society·Manoj V MaddaliMaunank Shah
Sep 22, 2016·Journal of the International AIDS Society·Nicholas PetersdorfUNKNOWN HCV and HIV Transmission Working Group
Sep 20, 2017·AIDS·Alicia C ThorntonUNKNOWN UK Collaborative HIV cohort (UK CHIC) steering committee
Aug 25, 2011·The Proceedings of the Nutrition Society·S M P KerrJ M W Wallace
Nov 20, 2013·Current Opinion in HIV and AIDS·Netanya G Sandler, Irini Sereti

❮ Previous
Next ❯

Related Concepts

Related Feeds

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.