PMID: 11924906Apr 2, 2002Paper

Death receptor ligands in tumors

Journal of Immunotherapy
Paola CappelloMirella Giovarelli

Abstract

Activation of apoptosis via death receptors is a tightly regulated event, and the death pathway itself is open to interference on the part of soluble or membrane-bound decoy receptors. The aggregation state of the death-inducing ligand is a crucial factor, particularly when these molecules are used as recombinant drugs against tumors. Whether tumors are sensitive to such ligands is determined by both the net abundance of death receptors versus decoy receptors and the balance between intracellular apoptotic and antiapoptotic mechanisms. This means that in vivo elimination of tumor cells by effector arms such as T lymphocytes, natural killer cells, macrophages, and dendritic cells is dependent on both the function of activated lymphoid cells and the genetic properties of tumor cells. Death receptor ligands, however, may be a double-edged sword. When expressed on cytotoxic T lymphocytes, natural killer cells, monocytes, and dendritic cells, they induce the apoptosis of many tumor cells, whereas their expression on tumor cells induces the apoptosis of killer cells. The in vivo result is influenced by the number of infiltrating cells, their state of activation, the cytokine repertoire in the tumor microenvironment, and the ability o...Continue Reading

References

May 7, 1992·Nature·R J ArmitageC R Maliszewski
Jan 1, 1991·Annual Review of Immunology·P L Cohen, R A Eisenberg
Mar 16, 1989·Nature·E Y JonesN P Walker
Dec 1, 1995·The Journal of Experimental Medicine·N KayagakiH Yagita
Nov 17, 1995·Science·J W Streilein
Nov 17, 1995·Science·T S GriffithT A Ferguson
Mar 10, 1995·Science·S Nagata, P Golstein
Apr 7, 1995·Cell·G Berke
Jun 1, 1995·Current Opinion in Immunology·J H Russell
Oct 19, 1995·Nature·D BellgrauR C Duke
Aug 26, 1993·Nature·J OgasawaraS Nagata
Feb 22, 1996·Nature·H YagitaK Okumura
Mar 1, 1996·Nature Medicine·M TanakaS Nagata
May 3, 1996·Cell·R Tisch, H McDevitt
Jun 27, 1996·The New England Journal of Medicine·F Bazzoni, B Beutler
May 31, 1996·The Journal of Biological Chemistry·R M PittiA Ashkenazi
Jun 1, 1996·Current Biology : CB·S A MarstersA Ashkenazi
Nov 1, 1996·Science·D J Van AntwerpI M Verma
Dec 1, 1996·Nature Medicine·S Nagata
Feb 1, 1997·Nature Medicine·K SeinoH Yagita
Feb 1, 1997·The Journal of Clinical Investigation·P M StuartT A Ferguson
Feb 7, 1997·Cell·S Nagata
Sep 1, 1996·The Journal of Experimental Medicine·J O'ConnellF Shanahan
Sep 1, 1996·The Journal of Experimental Medicine·S L PengJ Craft
Apr 4, 1997·Science·G PanV M Dixit
Apr 4, 1997·Cell·A V ChervonskyL A Matis
Apr 15, 1997·Proceedings of the National Academy of Sciences of the United States of America·J AllisonD L Vaux

❮ Previous
Next ❯

Citations

Sep 19, 2008·Journal of Pediatric Hematology/oncology·Paul T JubinskyMary K Short
Oct 31, 2002·Nature Immunology·Hung T Khong, Nicholas P Restifo
Jun 26, 2007·Journal of Dental Research·A OrozcoG J Seymour
Dec 30, 2003·International Journal of Cancer. Journal International Du Cancer·Christine LambertJuergen Frank
Jan 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christopher E TouloukianNicholas P Restifo
Apr 13, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jiehua ZhouEdward D Ball
Nov 3, 2007·Cancer Research·Kristy M GreeneltchScott I Abrams

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptotic Caspases

Apoptotic caspases belong to the protease enzyme family and are known to play an essential role in inflammation and programmed cell death. Here is the latest research.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.