Death receptor signaling in cancer therapy

Current Medicinal Chemistry. Anti-cancer Agents
Simone Fulda, Klaus-Michael Debatin

Abstract

Apoptosis, the cell's intrinsic death program, is a key regulator of tissue homeostasis. An imbalance between cell death and proliferation may result in tumor formation. Also, killing of cancer cells by cytotoxic therapies, such as chemotherapy, gamma-irradiation or ligation of death receptors is predominantly mediated by triggering apoptosis in target cells. Death receptor signaling pathways have been implied to contribute to the efficacy of cancer therapy. Failure to undergo apoptosis in response to anticancer therapy may lead to resistance. Understanding the molecular events that regulate apoptosis induced by anticancer therapy and how cancer cells evade apoptosis may provide new opportunities for drug development. Thus, novel strategies targeting tumor cell resistance will be based on insights into the molecular mechanisms of cell death.

Citations

Jan 16, 2007·Apoptosis : an International Journal on Programmed Cell Death·Daniel SaganHedda Eichholtz-Wirth
Aug 12, 2010·Journal of Experimental & Clinical Cancer Research : CR·Jun-Wei LiuDong-Sheng Huang
Dec 9, 2004·Expert Opinion on Therapeutic Targets·Benjamin D HedleyAnn F Chambers
Sep 24, 2004·International Journal of Cancer. Journal International Du Cancer·Anne-Odile HueberMartin Zörnig
Mar 30, 2010·Bioorganic & Medicinal Chemistry Letters·Souichi NakashimaMasayuki Yoshikawa
Jan 19, 2005·The Journal of Investigative Dermatology·Lothar F FeckerJürgen Eberle
May 7, 2008·Journal of Cellular Biochemistry·Jessica PlatiRoya Khosravi-Far
Jul 29, 2006·Cancer Detection and Prevention·Simone Fulda, Klaus-Michael Debatin
Jan 18, 2006·Bioorganic & Medicinal Chemistry Letters·Hisashi MatsudaMasayuki Yoshikawa
Apr 2, 2009·Chemical & Pharmaceutical Bulletin·Hisashi MatsudaMasayuki Yoshikawa
May 20, 2004·Cancer Research·Sandrine LacourMarie-Thérèse Dimanche-Boitrel

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.