Death the Fas way: regulation and pathophysiology of CD95 and its ligand

Pharmacology & Therapeutics
K SharmaY F Shi

Abstract

Apoptotic cell death mediated by the members of the tumor necrosis factor receptor family is an essential process involved in the regulation of cellular homeostasis during development, differentiation, and pathophysiological conditions. Among the cell death receptors comprising the tumor necrosis factor receptor superfamily, CD95/APO-1 (Fas) is the best characterized. The specific interaction of Fas with its cognate ligand, Fas ligand (FasL), elicits the activation of a death-inducing caspase (cysteine aspartic acid proteases) cascade, occurring in a transcription-independent manner. Caspase activation executes the apoptosis process by cleaving various intracellular substrates, leading to genomic DNA fragmentation, cell membrane blebbing, and the exposure of phagocytosis signaling molecules on the cell surface. Recent studies have shown that the Fas/FasL pathway plays an important role in regulating the life and death of the immune system through activation-induced cell death. In addition, these molecules have been implicated in aging, human immunodeficiency virus infection, drug abuse, stress, and cancer development. In this review, we will focus on the mechanisms that regulate Fas and FasL expression, and how their deregulati...Continue Reading

References

Oct 1, 1991·Immunology Letters·J LevineD I Beller
Apr 1, 1990·Journal of Autoimmunity·P A Singer, A N Theofilopoulos
Oct 6, 1989·Cell·P Gardner
Apr 1, 1989·British Medical Bulletin·J J Owen, E J Jenkinson
Feb 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·W F DavidsonH C Morse
Nov 17, 1995·Science·T S GriffithT A Ferguson
Jan 1, 1995·The Journal of Experimental Medicine·M R AldersonD H Lynch
Mar 10, 1995·Science·S Nagata, P Golstein
Jan 1, 1995·Immunology Today·S Nagata, T Suda
Dec 1, 1994·Current Opinion in Immunology·G G SingerA K Abbas
Apr 1, 1995·Arthritis and Rheumatism·T NakajimaK Nishioka
May 1, 1995·The Journal of Experimental Medicine·H NakajimaP A Henkart
Jun 1, 1995·Current Opinion in Immunology·J H Russell
Oct 19, 1995·Nature·D BellgrauR C Duke
Feb 1, 1995·Seminars in Immunology·A S ShawY Zhu
Mar 15, 1993·Biochemical and Biophysical Research Communications·S KobayashiT Uede
Aug 1, 1993·The Journal of Experimental Medicine·J WuJ D Mountz
Jan 17, 1995·Proceedings of the National Academy of Sciences of the United States of America·K YazdanbakhshY Choi
Jun 1, 1994·Current Opinion in Immunology·D R Green, D W Scott
Dec 1, 1994·The Journal of Experimental Medicine·R P BissonnetteD R Green
Feb 15, 1996·European Journal of Biochemistry·A J HaleG T Williams
Apr 12, 1996·The Journal of Biological Chemistry·A PontonI Stamenkovic

❮ Previous
Next ❯

Citations

Apr 22, 2005·Apoptosis : an International Journal on Programmed Cell Death·A YoshimoriS Tanuma
May 16, 2006·Apoptosis : an International Journal on Programmed Cell Death·C LautretteM O Jauberteau
Nov 30, 2010·Bulletin of Experimental Biology and Medicine·S A IvanovaN A Bokhan
May 17, 2007·Neuroscience and Behavioral Physiology·S A IvanovaG G Simutkin
Feb 14, 2004·Cellular Immunology·Rita N BárciaJulie D McLeod
Mar 5, 2004·International Immunopharmacology·Genhong Yao, Yayi Hou
Oct 24, 2002·Biochemical Pharmacology·Gil MorMarijke Kamsteeg
Apr 17, 2003·Life Sciences·Umberto DianzaniUgo Ramenghi
May 29, 2003·Neuroscience·C LautretteM O Jauberteau
Mar 5, 2003·Brain, Behavior, and Immunity·Yufang ShiJian-nian Zhou
Sep 5, 2002·British Journal of Pharmacology·Peng ZhangPeter K Chiang
May 29, 2002·Proceedings of the National Academy of Sciences of the United States of America·Mitsuhiro KondoKoji Uchida
Jan 6, 2006·Journal of Clinical Pathology·K W ChanG Srivastava
Jul 1, 2008·American Journal of Respiratory Cell and Molecular Biology·Quanfu MaoMonique E De Paepe
Feb 20, 2010·Journal of Inflammation·Maria GaluppoSalvatore Cuzzocrea
Apr 28, 2012·Journal of Neuroinflammation·Emanuela EspositoSalvatore Cuzzocrea
Jul 17, 2004·Biological & Pharmaceutical Bulletin·Sei-ichi TanumaRyoko Takasawa
Jun 19, 2014·The Journal of Venomous Animals and Toxins Including Tropical Diseases·Tássia R CostaSuely V Sampaio
Apr 16, 2004·Proceedings of the National Academy of Sciences of the United States of America·Akihiro HasegawaMark I Greene
Jul 19, 2005·Life Sciences·Genhong YaoYayi Hou
Jan 14, 2011·Genes and Immunity·S WangN Shen
Feb 26, 2011·European Journal of Pharmacology·Stefania MondelloSalvatore Cuzzocrea
Mar 4, 2011·International Journal of Hygiene and Environmental Health·Qing ChenQingbin Zhang
Jan 5, 2011·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Emanuela MazzonSalvatore Cuzzocrea
Jan 22, 2003·The Journal of Investigative Dermatology·Mario PuvianiCarlo Pincelli
Apr 3, 2007·European Journal of Pharmacology·Jun WangGen-Cheng Wu
Dec 19, 2006·Biochemical and Biophysical Research Communications·Kazuki Omoteyama, Shoichi Inoue
Oct 20, 2004·Journal of Cellular and Molecular Medicine·G A DosreisW A Zin
Feb 7, 2004·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·F A SayaniK A Sharkey
Jun 18, 2004·Annals of the New York Academy of Sciences·Ofer BinahSarit Larisch
Jun 6, 2006·British Journal of Pharmacology·Annalisa ChiocchettiGrazia Lombardi
Jul 10, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M SleaterR G Gill

❮ Previous
Next ❯

Related Concepts

Related Feeds

HIV/AIDS-Related Malignancies

HIV/AIDS infection increases the risk of non-communicable diseases common in the aged including HIV/AIDS-related malignancies. Discover the latest research in HIV/AIDS-related malignancies.