Debate about TGFBR1 and the susceptibility to colorectal cancer.

World Journal of Gastrointestinal Oncology
Laura Valle

Abstract

Recent years have witnessed enormous progress in our understanding of the genetic predisposition to colorectal cancer (CRC). Estimates suggest that all or most genetic susceptibility mechanisms proposed so far, ranging from high-penetrance genes to low-risk alleles, account for about 60% of the population-attributable fraction of CRC predisposition. In this context, there is increasing interest in the gene encoding the transforming growth factor β receptor 1 (TGFBR1); first when over a decade ago a common polymorphism in exon 1 (rs11466445, TGFBR1*6A/9A) was suggested to be a risk allele for CRC, then when linkage studies identified the chromosomal region where the gene is located as susceptibility locus for familial CRC, and more recently when the allele-specific expression (ASE) of the gene was proposed as a risk factor for CRC. Published data on the association of TGFBR1 with CRC, regarding polymorphisms and ASE and including sporadic and familial forms of the disease, are often contradictory. This review gives a general overview of the most relevant studies in order to clarify the role of TGFBR1 in the field of CRC genetic susceptibility.

References

Jun 6, 1998·Science·J R HoweL A Aaltonen
Jun 9, 1999·International Journal of Cancer. Journal International Du Cancer·T ChenM Reiss
May 1, 2001·The Journal of Pathology·A A van TilborgE C Zwarthoff
Dec 18, 2001·Nature Genetics·Hai YanBert Vogelstein
Dec 18, 2001·Genes, Chromosomes & Cancer·W S SamowitzM L Slattery
Jun 22, 2002·Gut·R SalovaaraL A Aaltonen
Jul 27, 2002·Annual Review of Genomics and Human Genetics·William M Grady, Sanford D Markowitz
Aug 17, 2002·Science·Hai YanKenneth W Kinzler
Aug 30, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Virginia G KaklamaniBoris Pasche
Oct 21, 2003·Proceedings of the National Academy of Sciences of the United States of America·Georgia L WiesnerSanford D Markowitz
Feb 18, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Boris PascheTongzhang Zheng
Aug 12, 2004·International Journal of Cancer. Journal International Du Cancer·Qianren JinAsta Försti
Sep 24, 2004·International Journal of Cancer. Journal International Du Cancer·Taiping ChenJulia H Carter
Sep 24, 2004·BMC Genetics·Virginia KaklamaniBoris Pasche
Oct 27, 2004·Prostate Cancer and Prostatic Diseases·B K SuarezW J Catalona
Oct 29, 2004·Nature Reviews. Cancer·Albert de la Chapelle
Apr 30, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Yansong BianBoris Pasche
Jun 16, 2005·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Hong-Tao Zhang
Aug 6, 2005·Journal of Gastroenterology·Tatsuya AndoKazuyuki Suzuki
Oct 6, 2005·JAMA : the Journal of the American Medical Association·Boris PascheChristopher M Weghorst
Oct 8, 2005·Cancer Treatment and Research·Virginia Kaklamani, Boris Pasche
Oct 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hong-Tao ZhangXiao-Feng Chen
Nov 17, 2005·JAMA : the Journal of the American Medical Association·Kevin SweetCharis Eng
Jan 24, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Taiping ChenJulia H Carter
May 19, 2006·Cancer Research·Zoe E KempUNKNOWN Colorectal Tumour Gene Identification Study Consortium
Jun 16, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Heather Spencer FeigelsonEugenia E Calle
Jan 4, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Lauri AaltonenRichard Houlston
May 18, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Denise DaleyGeorgia L Wiesner
Jun 19, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Johanna SkoglundAnnika Lindblom
Jul 4, 2007·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Weiming YouHong-Tao Zhang
Sep 26, 2007·Human Molecular Genetics·Yanfei Xu, Boris Pasche

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