DEC1 and DEC2 Crosstalk between Circadian Rhythm and Tumor Progression

Journal of Cancer
Fuyuki SatoYasuteru Muragaki

Abstract

Clock genes, major regulators of circadian rhythm, are involved in tumor progression. We have shown that clock genes basic helix-loop-helix (BHLH) transcription factors, differentiated embryonic chondrocyte gene 1 (DEC1/BHLHE40/Sharp2/Stra13) and DEC2 (BHLHE41/Sharp1) play important roles in circadian rhythm, cell proliferation, apoptosis, hypoxia response, various stresses, and epithelial-to-mesenchymal transition (EMT) of tumor cells. Various stresses, such as exposure to transforming growth factor-beta (TGF-β), hypoxia, cytokines, serum-free, and anti-tumor drugs affect DEC1 and DEC2 expression. An increased or decreased expression of DEC1 and DEC2 regulated tumor progression. However, DEC1 and DEC2 have opposite effects in tumor progression, where the reason behind remains unclear. We found that DEC2 has circadian expression in implanted mouse sarcoma cells, suggesting that DEC2 regulates tumor progression under circadian rhythm. In addition to that, we showed that DEC1 and DEC2 regulate target genes via positive or negative feedback system in tumor progression. We propose that DEC1 and DEC2 act as an accelerator or a brake in tumor progression. In this review, we summarize current progress of knowledge in the function of D...Continue Reading

Citations

Apr 21, 2016·Journal of Experimental & Clinical Cancer Research : CR·Baoen JiangHongyan Tian
Mar 9, 2018·International Journal of Molecular Sciences·Fuyuki SatoYasuteru Muragaki
Dec 6, 2017·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Yanfei JiaXiaoli Ma
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Jul 20, 2017·Histochemistry and Cell Biology·Fuyuki SatoYasuteru Muragaki
Oct 23, 2020·Clocks & Sleep·Fuyuki SatoYasuteru Muragaki
Feb 10, 2021·Clocks & Sleep·Fuyuki SatoYasuteru Muragaki
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BETA
surgical resections

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