DEC1 (STRA13) protein expression relates to hypoxia- inducible factor 1-alpha and carbonic anhydrase-9 overexpression in non-small cell lung cancer

The Journal of Pathology
Alexandra GiatromanolakiAdrian L Harris

Abstract

Differentiated embryo-chondrocyte expressed gene 1 (DEC1) is involved in cell differentiation, proliferation, and apoptosis, and was recently shown to be regulated by hypoxia. The present immunohistochemical study demonstrates extensive nuclear expression of the protein in 38% of a series of 115 non-small cell lung carcinomas using a polyclonal antibody (Ab) recognizing DEC1 protein. Such expression was directly related to the expression of two hypoxia-regulated proteins, namely the hypoxia-inducible factor (HIF) 1alpha and carbonic anhydrase-9. Although DEC1 was not related to angiogenesis or to the expression of VEGF and thymidine phosphorylase, a direct association with up-regulated bFGF receptors was noted. DEC1 was persistently expressed in the nuclei of normal bronchial and alveolar tissue. It is suggested that loss of DEC1 expression is an early event in the development of lung cancer, while DEC1 gene expression occurs in a subset of tumours and parallels the overexpression of other hypoxia-regulated proteins.

References

Mar 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·M MakosS B Baylin
Jan 1, 1991·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J D Chapman
Apr 2, 1996·Proceedings of the National Academy of Sciences of the United States of America·M GassmannH Acker
Jul 8, 1998·Proceedings of the National Academy of Sciences of the United States of America·L E HuangH F Bunn
Oct 14, 1998·Cancer Metastasis Reviews·C Blancher, A L Harris
Oct 31, 1998·Current Opinion in Genetics & Development·G L Semenza
Mar 8, 2000·Molecular and Cellular Biochemistry·Y J Le, P M Corry
Mar 7, 2002·Proceedings of the National Academy of Sciences of the United States of America·Leigh ZawelShibin Zhou

❮ Previous
Next ❯

Citations

Mar 13, 2003·European Journal of Nuclear Medicine and Molecular Imaging·J G RajendranK A Krohn
Feb 21, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yang LiuEn-Hua Wang
Jun 7, 2005·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Seok Jin KimMichael J Kelley
Jul 25, 2009·Omics : a Journal of Integrative Biology·Yan ZhengYuping Sun
Mar 13, 2009·Genes & Development·Andrew R J YoungMasashi Narita
Apr 30, 2011·World Journal of Gastroenterology : WJG·Xiao-Hong ShiYun-Shan Wang
Jun 1, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Jörg J JacobyRoy S Herbst
Oct 30, 2012·Journal of Pain and Symptom Management·Bruno GagnonDavid V Morris
Sep 9, 2010·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Sanghui ParkEun Kyung Cho
Sep 25, 2010·Biochemical and Biophysical Research Communications·Weibin WangJörg Kleeff
Apr 21, 2011·The Journal of Pathology·Ujjal K BhawalSadao Sato
Mar 20, 2010·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Yang LiuHiroshi Kijima
Apr 6, 2005·Cancer Letters·Chandrakala Menon, Douglas L Fraker
Apr 20, 2004·International Journal of Radiation Oncology, Biology, Physics·Michael I KoukourakisUNKNOWN Tumour and Angiogenesis Research Group
May 9, 2006·Gene Expression Patterns : GEP·Jihua YaoJinglun Xue
Jun 16, 2009·The Biochemical Journal·Sheng P HsiaoShen L Chen
Nov 16, 2010·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Sigve AndersenRoy M Bremnes
Jan 5, 2008·BMC Cancer·Sally JärveläHannu Haapasalo
Apr 22, 2015·Environment International·Somnath Paul, Ashok K Giri
Mar 4, 2006·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Lisa SimiClaudio Orlando
Nov 22, 2008·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Francesca MalentacchiClaudio Orlando
Sep 15, 2004·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Vienna LudoviniMaurizio Tonato
Jun 28, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Zhao-Jia GaoKai Yuan
Dec 6, 2017·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Yanfei JiaXiaoli Ma
May 31, 2018·Cancer Medicine·Camille EmprouMichèle Beau-Faller

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis