journal cover

Decanalization, brain development and risk of schizophrenia

Translational Psychiatry

Jun 28, 2011

John Joseph McGrathGary E. Gibson

Get paper from

Abstract

Waddington's original description of canalization refers to the ability of an organism to maintain phenotypic fidelity in the face of environmental and/or genetic perturbation. Development of the human brain requires exposure to a 'wild-type' environment-one that supports the optimal se...read more

Mentioned in this Paper

Schizophrenia
Organism
Genetic Translation Process
Brain Development
Brain
Asthenia
Gene-Environment Interaction
Neocortex
Epigenomics
2
43
Paper Details
References
  • References55
  • Citations14
12345...
  • References55
  • Citations14
12

Decanalization, brain development and risk of schizophrenia

Translational Psychiatry

Jun 28, 2011

John Joseph McGrathGary E. Gibson

PMID: 22832430

DOI: 10.1038/tp.2011.16

Abstract

Waddington's original description of canalization refers to the ability of an organism to maintain phenotypic fidelity in the face of environmental and/or genetic perturbation. Development of the human brain requires exposure to a 'wild-type' environment-one that supports the optimal se...read more

Mentioned in this Paper

Schizophrenia
Organism
Genetic Translation Process
Brain Development
Brain
2
43

Related Papers

Paper Details
References
  • References55
  • Citations14
12345...
  • References55
  • Citations14
12

Get paper from

/papers/decanalization-brain-development-and-risk-of/22832430