Decarboxylative C-H arylation of benzoic acids under radical conditions

Organic Letters
Sangwon SeoMichael F Greaney

Abstract

A decarboxylative radical cyclization reaction has been developed for the synthesis of fluorenones. The reaction uses Ag(I)/K2S2O8 to oxidatively decarboxylate an aroylbenzoic acid to an aryl radical, which undergoes cyclization to afford fluorenone products in good yield.

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Citations

Feb 3, 2016·Organic Letters·Xue-Qiang ChuShun-Jun Ji
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