Decay of mitochondrial metabolic competence in the aging cerebellum

Annals of the New York Academy of Sciences
C Bertoni-FreddariT Casoli

Abstract

Cytochemically evidenced cytochrome oxidase activity was morphometrically measured in the cerebellar cortex of adult and old rats. The ratio (R) between the area of the precipitate due to the cytochemical reaction and the overall area of each mitochondrion was calculated. While in adult rats an inverse correlation between mitochondrial size and R values (r = -.905) was envisaged, in old animals increasing values of R were paired by increases in mitochondrial area (r =.561). Paired-quartile comparisons of the R values from adult and old animals documented a marked age-related impairment of the mitochondrial metabolic competence in small (I quartile: -31.6%) and medium-sized (II quartile: -26.4; III quartile: -16.4) mitochondria, while large organelles showed the lowest age-related decrease (IV quartile: -3.0%). The present findings support that a marked dysfunction of small and medium-sized mitochondria contributes to the significant decay of energy metabolism currently reported in physiological aging.

References

Jan 1, 1992·Trends in Neurosciences·R E Coggeshall
Mar 1, 1989·Trends in Neurosciences·M T Wong-Riley
Aug 26, 1999·Gerontology·W A Meier-Ruge, C Bertoni-Freddari
Jun 17, 2000·Trends in Neurosciences·M F Beal
Nov 9, 2000·Micron : the International Research and Review Journal for Microscopy·C Bertoni-FreddariW Meier-Ruge
Apr 29, 2004·Gerontology·Carlo Bertoni-FreddariWilliam Meier-Ruge

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Citations

Oct 22, 2008·Experimental Neurology·Torrie T Jones, Gregory J Brewer

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