PMID: 41984Oct 1, 1979

Decay pattern of rabbit erythrocyte hexokinase in cell aging

Mechanisms of Ageing and Development
M MagnaniG Fornaini

Abstract

As previously reported, during rabbit red blood cell aging glucose phosphorylating activities show several modifications. In the first period of the red cell life span the predominant form is similar to hexokinase II, while in the mature erythrocyte the predominant glucose phosphorylating activity resembles hexokinase I. In the oldest cells glucose phosphorylating activity has a low affinity (high Km) for glucose. In this paper the modifications of hexokinase in cell aging have been studied in vivo in a young erythrocyte population synchronized by actinomycin D, and in vitro in red cells separated in fractions according to different ages. Since protein synthesis is lacking in the mature red cell, we are inclined to explain the presence of low-affinity hexokinase activity in the oldest erythrocytes as an age-dependent transformation of a primary hexokinase.

References

Jan 1, 1978·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·M MagnaniG Fornaini
Oct 1, 1977·Clinica Chimica Acta; International Journal of Clinical Chemistry·G RijksenG E Staal
Oct 1, 1978·Mechanisms of Ageing and Development·G FornainiV Stocchi
Dec 15, 1975·Clinica Chimica Acta; International Journal of Clinical Chemistry·P A RogersH Harris
Jan 1, 1976·Vox Sanguinis·A M GanzoniH R Marti
Dec 1, 1970·European Journal of Biochemistry·G K GerberS M Rapoport
Apr 1, 1968·Proceedings of the Society for Experimental Biology and Medicine·C Van Gastel, C Bishop
Jan 19, 1974·Clinica Chimica Acta; International Journal of Clinical Chemistry·B M TurnerH Harris
Jul 1, 1971·The Journal of Clinical Investigation·A M GanzoniR S Hillman
Sep 9, 1980·Biochimica Et Biophysica Acta·M MagnaniG Fornaini

Citations

Aug 31, 1989·Clinica Chimica Acta; International Journal of Clinical Chemistry·P NassiG Ramponi
Mar 1, 1982·Mechanisms of Ageing and Development·M MagnaniG Fornaini
Jul 1, 1983·Mechanisms of Ageing and Development·M MagnaniG Fornaini
Jun 1, 1987·Mechanisms of Ageing and Development·V StocchiG Fornaini
Jun 1, 1987·Mechanisms of Ageing and Development·G LiguriG Ramponi
Apr 1, 1989·Mechanisms of Ageing and Development·A C McLellan, P J Thornalley
Feb 1, 1993·Mechanisms of Ageing and Development·H HrusovaM Magnani
Oct 23, 2002·Acta histochemica·Enrica BiagiottiPaolino Ninfali
Jun 1, 1985·Archives of Biochemistry and Biophysics·G FornainiM Dachà
Sep 1, 1985·British Journal of Haematology·M MagnaniG Fornaini
Nov 3, 1980·FEBS Letters·M MagnaniG Fornaini
Jan 1, 1985·Experimental Aging Research·W P Paré
Jan 1, 1981·American Journal of Hematology·D E PagliaW N Valentine

Related Concepts

Cell Fractionation
Centrifugation, Density Gradient
Erythrocyte Survival
Erythrocytes
Hexokinase 2
Hydrogen-Ion Concentration

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