Decellularized orthopaedic tissue-engineered grafts: biomaterial scaffolds synthesised by therapeutic cells

Biomaterials Science
Xiaolei Nie, Dong-An Wang

Abstract

In orthopaedic surgery, the reconstruction of musculoskeletal defects is a constant challenge. Biomaterials in tissue engineering are utilized as scaffolds which serve as templates for cell proliferation and secretion as well as guides for new tissue formation. The extracellular matrix (ECM) is a desirable biological scaffold due to its complex composition and three-dimensional ultrastructure, which drive the homeostasis and regeneration of tissues. Successfully used in a variety of regenerative medicine applications, ECM scaffolds can be achieved by decellularization of engineered tissue. In addition to using decellularized grafts directly as scaffolds, decellularized grafts can also be coated on or incorporated into synthetic biomaterials to substantially enhance their biological performance regarding integration into the surrounding tissue and bioactivity for neo-tissue generation. However, at present, the most widely adopted decellularized scaffolds are decellularized native scaffolds, which have the limitations of inherent heterogeneity, fixed shapes and insufficient sources. Decellularized tissue-engineered scaffolds are promising to avoid these restrictions and are receiving attention in the regenerative medicine field. ...Continue Reading

References

Oct 6, 1994·The New England Journal of Medicine·M BrittbergL Peterson
Feb 24, 1999·Clinics in Sports Medicine·T Minas, L Peterson
Nov 1, 2001·Annual Review of Cell and Developmental Biology·M D Sternlicht, Z Werb
Apr 26, 2003·Matrix Biology : Journal of the International Society for Matrix Biology·Ranieri CanceddaRodolfo Quarto
Oct 7, 2003·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Stephen F BadylakEdward McPherson
May 26, 2004·Transplant Immunology·Stephen F Badylak
Mar 16, 2005·Journal of Vascular Surgery·John D KakisisBauer E Sumpio
Apr 14, 2005·Journal of the American Veterinary Medical Association·Jeffrey D WoodStephen F Badylak
Feb 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Néha DattaAntonios G Mikos
Apr 4, 2006·Tissue Engineering·Bryan BrownStephen F Badylak
Aug 23, 2006·Cell·Adam J EnglerDennis E Discher
Sep 15, 2006·Journal of the Royal Society, Interface·Yoshito Ikada
May 6, 2008·Best Practice & Research. Clinical Rheumatology·Johanne Martel-PelletierPeter J Roughley
Oct 22, 2008·Acta Biomaterialia·Stephen F BadylakThomas W Gilbert
Mar 10, 2009·BMC Biotechnology·Genya MitaniJoji Mochida
Mar 31, 2009·Journal of Materials Science. Materials in Medicine·A Champa Jayasuriya, Nabil A Ebraheim
Oct 27, 2009·Developmental Biology·Tania Rozario, Douglas W DeSimone
Feb 5, 2010·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Andreas H GomollElizaveta Kon
Mar 13, 2010·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Scott M VickersMyron Spector
Jun 23, 2010·Journal of Biomaterials Science. Polymer Edition·Chuck B ThomasKaren J L Burg
Jul 14, 2010·Clinical Orthopaedics and Related Research·Farshid GuilakJeffrey M Gimble
Jul 22, 2010·Journal of Biomedical Materials Research. Part a·Le-Ping YanRui L Reis
Jul 30, 2010·Tissue Engineering. Part a·Yihong GongDong-An Wang
Sep 8, 2010·Journal of Biomechanical Engineering·Mary PhillipsBoris Rubinsky
Dec 3, 2010·Journal of Cell Science·Christian FrantzValerie M Weaver
Jan 8, 2011·Biomaterials·Hongxu LuGuoping Chen
Jan 21, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yun SunXiao-Dong Chen
Mar 1, 2011·Upsala Journal of Medical Sciences·Tomoya KurodaRyosuke Kuroda
Mar 2, 2011·The Journal of Vascular Access·Wojciech WystrychowskiNicolas L'heureux
May 24, 2011·European Cells & Materials·Ana M C BarradasPamela Habibovic
Sep 3, 2011·The Open Orthopaedics Journal·Frances Henson, Alan Getgood
Nov 15, 2011·Acta Biomaterialia·Martin L DecarisJ Kent Leach
Jan 24, 2012·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Chia-Chun ChenHsu-Wei Fang
Jun 2, 2012·Tissue Engineering. Part a·Martin L DecarisJ Kent Leach
Jul 17, 2012·Osteoarthritis and Cartilage·M M J CaronT J M Welting
Nov 1, 2009·Sports Health·Alice J Sophia FoxScott A Rodeo

❮ Previous
Next ❯

Citations

May 10, 2019·Regenerative Medicine·Cailing TongZhongquan Qi
May 1, 2020·Frontiers in Cardiovascular Medicine·Andras P DurkoJolanda Kluin
Aug 28, 2020·APL Bioengineering·Wenzhen ZhuDong-An Wang
Jun 20, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Chao TaoDong-An Wang
Feb 3, 2021·International Journal of Biological Macromolecules·Carlos Rhamon do N FerreiraJeanny da S Maciel
Mar 20, 2021·Journal of Tissue Engineering·Mahsa Nouri BarkestaniSara Shamdani
Apr 20, 2021·Advanced Healthcare Materials·Chao Tao, Dong-An Wang
Jun 8, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Piyali DasSamit Kumar Nandi

❮ Previous
Next ❯

Methods Mentioned

BETA
rheology
bioprinting

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Antiparasitics

Antiparasitics are medications which are indicated for the treatment of parasitic diseases. Discover the latest research on antiparasitics here.

Related Papers

Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
Yu ZhaoShuling Bai
Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi
Jiaoming DongDakai Chen
Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
Hana HrebikovaJaroslav Mokry
© 2022 Meta ULC. All rights reserved