Decellularized tendon as a prospective scaffold for tendon repair

Materials Science & Engineering. C, Materials for Biological Applications
Shengyu WangXianfeng Lin

Abstract

Tendon injuries impose significant clinical burdens on healthcare systems worldwide. At present, no therapeutic methods can cure tendon injuries in an ideal manner. With the development and improvement of decellularization technology, tendon extracellular matrix (ECM) can develop into novel scaffolds with potential for repairing injured tendons. Proper agents and decellularization protocols were developed to obtain tendon ECMs, and the method used to recellularize the tendon ECM was explored to create bio-functional neo-tendons for transplants. Further, preliminary testing was done to evaluate the reparative capacity of decellularized tendon scaffolds (DTSs). Here, we assess developments in tendon decellularization and recellularization processes, as well as the possibility for advancing DTSs into clinical applications based on recent findings.

Citations

Jan 24, 2019·Cell and Tissue Banking·Riccardo D'AmbrosiNicola Ursino
Aug 15, 2019·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Nandaraj TayeDirk Hubmacher
Feb 29, 2020·International Journal of Molecular Sciences·Yikan SunWilliam R Walsh
Jun 12, 2020·Tissue Engineering. Part a·Ortal ShelahAyelet Lesman
Sep 22, 2019·International Journal of Molecular Sciences·Kevin DzoboAdetola Adesida
May 29, 2020·The British Journal of Surgery·L EdgarG Orlando
Oct 19, 2020·BMC Musculoskeletal Disorders·Alex de Lima SantosFlavio Faloppa

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