Decentralized, Community-Based Hepatitis C Point-of-Care Testing and Direct-Acting Antiviral Treatment for People Who Inject Drugs and the General Population in Myanmar: Protocol for a Feasibility Study

JMIR Research Protocols
Bridget Louise DraperMargaret Hellard

Abstract

The advent of direct-acting antivirals (DAAs) and point-of-care (POC) testing platforms for hepatitis C allow for the decentralization of care to primary care settings. In many countries, access to DAAs is generally limited to tertiary hospitals, with limited published research documenting decentralized models of care in low-and middle-income settings. This study aims to assess the feasibility, acceptability, effectiveness, and cost-effectiveness of decentralized community-based POC testing and DAA therapy for hepatitis C among people who inject drugs and the general population in Yangon, Myanmar. Rapid diagnostic tests for anti-hepatitis C antibodies were carried out on-site and, if reactive, were followed by POC GeneXpert hepatitis C RNA polymerase chain reaction tests. External laboratory blood tests to exclude other major health issues were undertaken. Results were given to participants at their next appointment, with the participants commencing DAA therapy that day if a specialist review was not required. Standard clinical data were collected, and the participants completed behavioral questionnaires. The primary outcome measures are the proportion of participants receiving GeneXpert hepatitis C RNA test, the proportion of ...Continue Reading

References

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Citations

Feb 1, 2021·The International Journal on Drug Policy·Pablo RyanSalvador Resino
Jul 31, 2021·The Lancet Regional Health. Western Pacific·Nick ScottMargaret Hellard
Jun 22, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Bridget Louise DraperMargaret Hellard

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Methods Mentioned

BETA
PCR
blood draw

Clinical Trials Mentioned

NCT03939013

Software Mentioned

Stata
Research Electronic Data Capture ( REDCap )
Stata SE
GeneXpert
OpenMRS
REDCap
NVivo
QuickStart
Open Medical Records System ( OpenMRS )

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