Deciding Among Noninvasive Tools for Predicting Varices Needing Treatment in Chronic Liver Disease: An Analysis of Asian Cohort.

The American Journal of Gastroenterology
Sanchit SharmaAnoop Saraya

Abstract

Both transient elastography (TE)-based and non-TE-based criteria exist for detection of varices needing treatment (VNT) in patients with asymptomatic advanced chronic liver disease (CLD). However, their performance in clinical settings at different risk thresholds of detection of VNT and in regions where elastography is not widely available is unknown. We aimed to validate existing noninvasive criteria in our patients with CLD and identify best TE- and non-TE-based criteria for VNT screening at usual risk thresholds. Patients with compensated advanced CLD (cACLD) who underwent esophagogastroduodenoscopy and TE within 3 months were included. Diagnostic performance of Baveno VI, expanded Baveno VI, platelet-model for end-stage liver disease, and platelet-albumin (Rete Sicilia Selezione Terapia-hepatitis C virus) criteria were estimated. Decision curve analysis was conducted for different predictors across range of threshold probabilities. A repeat analysis including all patients with compensated CLD (cACLD and non-cACLD) was performed to simulate absence of TE. A total of 1,657 patients (cACLD, 895; non-cACLD, 762) related to hepatitis B virus (38.2%), hepatitis C virus (33.4%), nonalcoholic steatohepatitis (14.7%), and alcohol (...Continue Reading

References

Oct 13, 1988·The New England Journal of Medicine·UNKNOWN North Italian Endoscopic Club for the Study and Treatment of Esophageal Varices
Nov 14, 2006·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Andrew J Vickers, Elena B Elkin
Aug 31, 2007·The American Journal of Gastroenterology·Guadalupe Garcia-TsaoUNKNOWN Practice Parameters Committee of American College of Gastroenterology
Mar 5, 2010·The New England Journal of Medicine·Guadalupe Garcia-Tsao, Jaime Bosch
Feb 6, 2017·Liver International : Official Journal of the International Association for the Study of the Liver·Parastoo JangoukGuadalupe Garcia-Tsao
Jul 12, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Salvador AugustinJoan Genescà
Mar 2, 2018·Liver International : Official Journal of the International Association for the Study of the Liver·Joohwan BaeSeung Woon Paik
Aug 31, 2018·Nature Reviews. Gastroenterology & Hepatology·Martin C S WongSiew C Ng
Sep 14, 2018·Annals of Translational Medicine·Zhongheng ZhangUNKNOWN written on behalf of AME Big-Data Clinical Trial Collaborative Group
Dec 28, 2018·Liver International : Official Journal of the International Association for the Study of the Liver·Han Ah LeeSoon Ho Um
Feb 16, 2019·Journal of Clinical and Experimental Hepatology·Gyanranjan Rout Shalimar
May 12, 2019·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Maria StafylidouApostolos Tsapas
May 29, 2019·The American Journal of Gastroenterology·Vincenza CalvarusoUNKNOWN RESIST-HCV (Rete Sicilia Selezione Terapia–HCV)
Oct 2, 2019·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Avik Majumdar, Emmanuel A Tsochatzis
Oct 9, 2019·Diagnostic and Prognostic Research·Andrew J VickersEwout W Steyerberg

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