PMID: 8962652Mar 1, 1996Paper

Decidua as a site of extrathymic V gamma I T-cell differentiation

American Journal of Reproductive Immunology : AJRI
S HayakawaK Satoh

Abstract

Decidual tissue is an interface between the host and fetus, which is regarded as a natural allograft. We have reported the possible presence of extrathymic T cells in human decidua through the expression of recombinase-activating genes in the decidual CD16-CD56bright large granular lymphocytes. In this study we analyzed expression of TCR V gamma delta gene segments in peripheral lymphocytes and decidual and nonpregnant endometrial samples using RT-PCR and oligonucleotide hybridization. Interestingly, a limited repertoire of V gamma gene segments were discovered in decidual lymphocytes of normal pregnancy when compared with peripheral lymphocytes, whereas usage of V delta gene segments were ubiquitous in peripheral and decidual lymphocytes. Strong expression of V gamma I gene segment, often exceeding 50% of total V gamma, were noted in all (13/13) pregnant decidual tissues obtained at different gestational stages. Interestingly, this predominance of V gamma I gene is also noted in nonpregnant endometrial samples and the decidua of patients with ectopic pregnancies. Our results suggest the nature of decidual V gamma I T cells as possible suppressors of rejective maternal cytotoxic T cells during the maintenance of normal pregnanc...Continue Reading

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Citations

Sep 21, 2000·Journal of Reproductive Immunology·E C Segerson, P K Beetham
Aug 5, 2000·Journal of Reproductive Immunology·S Saito
Oct 10, 2007·Biochemistry. Biokhimii︠a︡·S V ShirshevN S Parshakova
Apr 27, 2013·International Reviews of Immunology·Leonardo M R Ferreira
Sep 27, 2002·American Journal of Reproductive Immunology : AJRI·Fumihisa ChishimaMitsuo Honda
Oct 23, 2012·Cellular & Molecular Immunology·Shirin Kalyan, Dieter Kabelitz
Jan 23, 1999·Biology of Reproduction·P ArckD Clark

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