Decidua-associated suppressor cells in abortion-prone DBA/2-mated CBA/J mice that release bioactive transforming growth factor beta2-related immunosuppressive molecules express a bone marrow-derived natural suppressor cell marker and gamma delta T-cell receptor

Biology of Reproduction
D A ClarkH Hirte

Abstract

The decidua of allopregnant mice contains a novel population of Thy1 Lyt1 CD4 CD8 asialoGM1- non-B small lymphocytic suppressor cells that release transforming growth factor (TGF) SS2-related suppressor molecules. The "null" phenotype of this cell population is similar to some bone marrow-derived natural suppressor cell (NSC) populations, and the latter may release TGF(beta)s. We now report that the TGF beta2-producing suppressor cells in the uterine decidua of DBA/2-mated CBA/J female mice-linked to prevention of abortions-are inactivated effectively by 1E5/B5.1 but not by 2C1.1 rat monoclonal antibodies to murine pregnancy-associated splenic NSC in the presence of complement. Immunostaining of a subpopulation of cells in decidua with 1E5/B5.1 but not with 2C1.1 was shown by flow cytometry. Release of suppressor factor was also abrogated by 1E5/B5.1 + complement but not by 2C1.1 + complement, and the suppressor factor was specifically neutralized by anti-TGF beta2 and not by anti-TGF beta3. Splenic pregnancy NSC are susceptible to 2C1.1, produce TGF beta1, and express CD3 and alpha beta T-cell receptor (TcR) chains. Release of suppressor factor by the decidual NSC was abrogated by treatment with anti-CD3 (145 2C11) and anti-Tc...Continue Reading

Citations

Jun 30, 2001·Obstetrics and Gynecology·R RaghupathyL Ashkanani
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Oct 1, 1990·American Journal of Reproductive Immunology : AJRI·D A Clark
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Jan 30, 2014·Reproduction : the Official Journal of the Society for the Study of Fertility·Elizabeth A Bonney, Stephen A Brown
Oct 10, 2007·American Journal of Reproductive Immunology : AJRI·Marianne J van den HeuvelDavid A Clark
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Aug 1, 2021·American Journal of Reproductive Immunology : AJRI·Qian-Han XuAi-Hua Liao

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