Decidual cytokines and pregnancy complications: focus on spontaneous miscarriage

Journal of Reproductive Immunology
Gendie E Lash, Jan Ernerudh

Abstract

The establishment of pregnancy requires the co-ordinated implantation of the embryo into the receptive decidua, placentation, trophoblast invasion of the maternal decidua and myometrium in addition to remodelling of the uterine spiral arteries. Failure of any of these steps can lead to a range of pregnancy complications, including miscarriage, pre-eclampsia, fetal growth restriction, placenta accreta and pre-term birth. Cytokines are small multifunctional proteins often derived from leucocytes and have primarily been described through their immunomodulatory actions. The maternal-fetal interface is considered to be immunosuppressed to allow development of the semi-allogeneic placental fetal unit. However, cytokine profiles of the decidua and different decidual cell types suggest that the in vivo situation might be more complex. Data suggest that decidual-derived cytokines not only play roles in immunosuppression, but also in other aspects of the establishment of pregnancy, including the regulation of trophoblast invasion and spiral artery remodelling. This review focuses on the potential role of decidua-derived cytokines in the aetiology of unexplained spontaneous miscarriage.

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Citations

Nov 26, 2015·Journal of Reproductive Immunology·Ai-Min ZhaoLi-Ming Lu
May 31, 2016·Journal of Pregnancy·Kameliya VinketovaTsvetelina Oreshkova
May 28, 2016·Journal of Diabetes and Its Complications·Lauren Wedekind, Louiza Belkacemi
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Feb 13, 2020·Reproductive Sciences·Augustine RajakumarNeil Sidell
Dec 11, 2019·Cell Proliferation·Xiao-Wei GuZeng-Ming Yang
May 2, 2020·American Journal of Reproductive Immunology : AJRI·Hui-Li YangJun Shao
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Nov 14, 2019·International Journal of Molecular Sciences·Carlo TicconiAsgerally Fazleabas
May 20, 2020·International Journal of Molecular Sciences·Wittaya ChaiwangyenDiana M Morales-Prieto
May 22, 2019·BioMed Research International·Xiuhua Yang, Tao Meng
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Oct 22, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Xiaoling FengLing Wang
Aug 10, 2021·Frontiers in Medicine·Ana EspinoNabila Jabrane-Ferrat

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