Decidual glycodelin-A polarizes human monocytes into a decidual macrophage-like phenotype through Siglec-7.

Journal of Cell Science
Madhavi VijayanPhilip C N Chiu

Abstract

Decidual macrophages constitute 20-30% of the total leukocytes in the uterus of pregnant women, regulating the maternal immune tolerance and placenta development. Abnormal number or activities of decidual macrophages (dMs) are associated with fetal loss and pregnancy complications, such as preeclampsia. Monocytes differentiate into dMs in a decidua-specific microenvironment. Despite their important roles in pregnancy, the exact factors that regulate the differentiation into dMs remain unclear. Glycodelin-A (PAEP, hereafter referred to as GdA) is a glycoprotein that is abundantly present in the decidua, and plays an important role in fetomaternal defense and placental development. It modulates the differentiation and activity of several immune cell types residing in the decidua. In this study, we demonstrated that GdA induces the differentiation of human monocytes into dM-like phenotypes in terms of transcriptome, cell surface marker expression, secretome, and regulation of trophoblast and endothelial cell functions. We found that Sialic acid-binding Ig-like lectin 7 (Siglec-7) mediates the binding and biological actions of GdA in a sialic acid-dependent manner. We, therefore, suggest that GdA, induces the polarization of monocy...Continue Reading

References

Sep 15, 1989·Clinica Chimica Acta; International Journal of Clinical Chemistry·L RiittinenM L Huhtala
Mar 31, 1999·Journal of Reproductive Immunology·W ChuJ S Hunt
Feb 28, 2003·Clinical and Experimental Immunology·J HeikkinenO Lassila
Dec 4, 2003·Reproductive Biology and Endocrinology : RB&E·Gil Mor, Vikki M Abrahams
Jun 26, 2004·Journal of Leukocyte Biology·Robert D Stout, Jill Suttles
Apr 1, 2005·Biology of Reproduction·Stephen J RenaudCharles H Graham
Jun 11, 2005·Science·Christopher W Redman, Ian L Sargent
Mar 24, 2007·Nature Reviews. Immunology·Paul R CrockerAjit Varki
Dec 18, 2007·Bioinformation·Lokesh Kumar, Matthias E Futschik
Nov 29, 2008·European Journal of Endocrinology·M SeppäläW S Yeung
Jan 21, 2009·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Claire E Routley, Gillian S Ashcroft
Feb 26, 2009·The Journal of Biological Chemistry·Cheuk-Lun LeePhilip C N Chiu
Jun 25, 2009·Scandinavian Journal of Clinical and Laboratory Investigation·Hannu KoistinenRiitta Koistinen
Dec 1, 2009·Fertility and Sterility·Cheuk-Lun LeeWilliam S B Yeung
Jan 19, 2010·Annual Review of Pathology·Brett C YoungS Ananth Karumanchi
Jan 25, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Brandy L HouserJack L Strominger
Mar 16, 2011·Annals of the New York Academy of Sciences·Gil MorSeth Guller
Jun 7, 2011·Journal of Reproductive Immunology·Cheuk-Lun LeePhilip C N Chiu
Sep 6, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Judit SvenssonJan Ernerudh
Jan 10, 2012·Annual Review of Immunology·Shiv PillaiHamid Mattoo
Nov 23, 2012·Reproductive Sciences·Kristen K RumerVirginia D Winn
Jan 10, 2013·Annual Review of Immunology·Adrian Erlebacher
Feb 4, 2014·Genome Biology·Charity W LawGordon K Smyth

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Citations

Mar 1, 2021·The Journal of Biological Chemistry·Atsushi YoshimuraChihiro Sato
Jun 8, 2021·Frontiers in Physiology·Lindsay Sawyer
Jul 3, 2021·Cells·Dorota M Radomska-LeśniewskaPaweł Kamiński

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