Decidualized pseudopregnant rat uterus shows marked reduction in Ang II and Ang-(1-7) levels

Placenta
K B BrosnihanL A A Neves

Abstract

Previous studies showed that angiotensin (Ang) II and Ang-(1-7) concentrations were reduced in the implantation site at day 7 of pregnancy in Sprague-Dawley rats as compared to the site immediately adjacent to it, which does not have the embryo attached, clearly showing the importance of the blastocyst in the regulation of renin-angiotensin system (RAS). The objective of this study was to evaluate the regulation of the RAS in the decidualized uterus in the pseudopregnant rat, a model without the presence of a conceptus. Ovariectomized, adult female rats were sensitized for the decidual cell reaction with steroid treatments; decidualization was induced by oil-injection of the right horn; the left horn served as a control. The uterine content of Ang I, Ang II, and Ang-(1-7) was examined in the decidualized and non-decidualized uteri. Both Ang-(1-7) and Ang II and ACE and ACE2 mRNA were significantly reduced in the decidualized horn as compared to the non-decidualized horn. Immunocytochemical characterization of Ang II, Ang-(1-7), ACE and ACE2 demonstrated that Ang-(1-7), Ang II, and ACE2 polarize to the anti-mesometrial pole with decidualization. The decidualization process elicits marked reduction in uterine Ang II and Ang-(1-7)...Continue Reading

References

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Citations

Jun 12, 2012·Journal of Molecular Histology·João Vaz-SilvaFernando M Reis
Dec 20, 2012·Clinical Science·Danielle G Passos-SilvaRobson A S Santos
Oct 21, 2016·Reproductive Biology and Endocrinology : RB&E·K Bridget BrosnihanLiliya M Yamaleyeva
May 5, 2020·Molecular Human Reproduction·Yan JingChen Fei
Jan 14, 2021·Middle East Fertility Society Journal·Indu SharmaSubhas Chandra Saha
Feb 2, 2021·Saudi Journal of Biological Sciences·Nesrein M HashemAyman A Swelum

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