Decidualized pseudopregnant rat uterus shows marked reduction in Ang II and Ang-(1-7) levels

K B BrosnihanL A A Neves


Previous studies showed that angiotensin (Ang) II and Ang-(1-7) concentrations were reduced in the implantation site at day 7 of pregnancy in Sprague-Dawley rats as compared to the site immediately adjacent to it, which does not have the embryo attached, clearly showing the importance of the blastocyst in the regulation of renin-angiotensin system (RAS). The objective of this study was to evaluate the regulation of the RAS in the decidualized uterus in the pseudopregnant rat, a model without the presence of a conceptus. Ovariectomized, adult female rats were sensitized for the decidual cell reaction with steroid treatments; decidualization was induced by oil-injection of the right horn; the left horn served as a control. The uterine content of Ang I, Ang II, and Ang-(1-7) was examined in the decidualized and non-decidualized uteri. Both Ang-(1-7) and Ang II and ACE and ACE2 mRNA were significantly reduced in the decidualized horn as compared to the non-decidualized horn. Immunocytochemical characterization of Ang II, Ang-(1-7), ACE and ACE2 demonstrated that Ang-(1-7), Ang II, and ACE2 polarize to the anti-mesometrial pole with decidualization. The decidualization process elicits marked reduction in uterine Ang II and Ang-(1-7)...Continue Reading


Aug 1, 1992·Journal of Reproduction and Fertility·P M Squires, T G Kennedy
Aug 1, 1982·Biology of Reproduction·T G Kennedy, L A Lukash
Jun 1, 1997·Biology of Reproduction·J CorthornG Valdés
Jun 30, 2000·Seminars in Cell & Developmental Biology·J Aplin
May 30, 2002·The Journal of Biological Chemistry·Hiromichi MatsumotoSudhansu K Dey
Jun 21, 2002·Nature·Michael A CrackowerJosef M Penninger
Sep 18, 2002·Kidney International·Carlos M FerrarioDebra I Diz
Jul 23, 2003·Hypertension·K Bridget BrosnihanCarlos M Ferrario
Oct 1, 2003·Circulation·David B AverillCarlos M Ferrario

❮ Previous
Next ❯


Jun 12, 2012·Journal of Molecular Histology·João Vaz-SilvaFernando M Reis
Dec 20, 2012·Clinical Science·Danielle G Passos-SilvaRobson A S Santos
Oct 21, 2016·Reproductive Biology and Endocrinology : RB&E·K Bridget BrosnihanLiliya M Yamaleyeva
May 5, 2020·Molecular Human Reproduction·Yan JingChen Fei
Jan 14, 2021·Middle East Fertility Society Journal·Indu SharmaSubhas Chandra Saha
Feb 2, 2021·Saudi Journal of Biological Sciences·Nesrein M HashemAyman A Swelum

❮ Previous
Next ❯

Related Concepts

Related Feeds


Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis