Deciphering Asthma Biomarkers with Protein Profiling Technology

International Journal of Inflammation
Zhizhou KuangRuo-Pan Huang

Abstract

Asthma is a chronic inflammatory disease of the airways, resulting in bronchial hyperresponsiveness with every allergen exposure. It is now clear that asthma is not a single disease, but rather a multifaceted syndrome that results from a variety of biologic mechanisms. Asthma is further problematic given that the disease consists of many variants, each with its own etiologic and pathophysiologic factors, including different cellular responses and inflammatory phenotypes. These facets make the rapid and accurate diagnosis (not to mention treatments) of asthma extremely difficult. Protein biomarkers can serve as powerful detection tools in both clinical and basic research applications. Recent endeavors from biomedical researchers have developed technical platforms, such as cytokine antibody arrays, that have been employed and used to further the global analysis of asthma biomarker studies. In this review, we discuss potential asthma biomarkers involved in the pathophysiologic process and eventual pathogenesis of asthma, how these biomarkers are being utilized, and how further testing methods might help improve the diagnosis and treatment strain that current asthma patients suffer.

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Citations

Feb 14, 2018·International Journal of Molecular Sciences·Wei HuangRuo-Pan Huang
Feb 3, 2018·Assay and Drug Development Technologies·Wei HuangRuo-Pan Huang
Mar 27, 2018·Expert Review of Respiratory Medicine·Job J M H van BragtAnke H Maitland-van der Zee
Apr 13, 2019·International Journal of Molecular Sciences·Zaida ZainalSui Kiat Chang

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Methods Mentioned

BETA
protein folding
bronchoalveolar lavage
biopsies
Antibody Array
ELISA

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