Deciphering Non-coding RNAs in Cardiovascular Health and Disease

Frontiers in Cardiovascular Medicine
Anindita DasFadi N Salloum

Abstract

After being long considered as "junk" in the human genome, non-coding RNAs (ncRNAs) currently represent one of the newest frontiers in cardiovascular disease (CVD) since they have emerged in recent years as potential therapeutic targets. Different types of ncRNAs exist, including small ncRNAs that have fewer than 200 nucleotides, which are mostly known as microRNAs (miRNAs), and long ncRNAs that have more than 200 nucleotides. Recent discoveries on the role of ncRNAs in epigenetic and transcriptional regulation, atherosclerosis, myocardial ischemia/reperfusion (I/R) injury and infarction (MI), adverse cardiac remodeling and hypertrophy, insulin resistance, and diabetic cardiomyopathy prompted vast interest in exploring candidate ncRNAs for utilization as potential therapeutic targets and/or diagnostic/prognostic biomarkers in CVDs. This review will discuss our current knowledge concerning the roles of different types of ncRNAs in cardiovascular health and disease and provide some insight on the cardioprotective signaling pathways elicited by the non-coding genome. We will highlight important basic and clinical breakthroughs that support employing ncRNAs for treatment or early diagnosis of a variety of CVDs, and also depict the ...Continue Reading

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Citations

Apr 6, 2019·Journal of Cellular Physiology·Xian-Jin DuXiaorong Hu
Aug 26, 2019·Metabolic Brain Disease·Elaheh HeydariAmir Anbiyaiee
Dec 6, 2019·Briefings in Bioinformatics·Bohdan B KhomtchoukThemistocles L Assimes
May 6, 2020·The FEBS Journal·Eithne Margaret Maguire, Qingzhong Xiao
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Jun 25, 2020·Neurotoxicity Research·Meng LuSeyed Esmaeil Khoshnam
Jan 23, 2021·Diagnostics·Nurruzanna IsmailSiti Aishah Sulaiman
Mar 30, 2021·Frontiers in Physiology·Magda CorreiaSandrina Nóbrega-Pereira

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Methods Mentioned

BETA
ChIP
GTPases
nuclear translocation
transfection
SMA
transgenic
biopsies
coronary artery ligation
coronary artery bypass
immunoprecipitation

Software Mentioned

Miragen
Chast

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