Deciphering Parameter Sensitivity in the BvgAS Signal Transduction

PloS One
Tarunendu MapderSuman K Banik

Abstract

To understand the switching of different phenotypic phases of Bordetella pertussis, we propose an optimized mathematical framework for signal transduction through BvgAS two-component system. The response of the network output to the sensory input has been demonstrated in steady state. An analysis in terms of local sensitivity amplification characterizes the nature of the molecular switch. The sensitivity analysis of the model parameters within the framework of various correlation coefficients helps to decipher the contribution of the modular structure in signal propagation. Once classified, the model parameters are tuned to generate the behavior of some novel strains using simulated annealing, a stochastic optimization technique.

References

Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·V ScarlatoR Rappuoli
May 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·C R RoyS Falkow
Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·V ScarlatoR Rappuoli
Nov 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·A Goldbeter, D E Koshland
Jul 16, 1982·Science·D E KoshlandJ B Stock
Apr 4, 2000·Current Opinion in Microbiology·J A Hoch
Aug 31, 2000·Annual Review of Biochemistry·A M StockP N Goudreau
Jan 11, 2003·Proceedings of the National Academy of Sciences of the United States of America·Eric Batchelor, Mark Goulian
Aug 14, 2003·Trends in Microbiology·Peggy A Cotter, Allison M Jones
Jul 14, 2005·Chemical Reviews·Andrea SaltelliFrancesca Campolongo
Jul 7, 2007·Proceedings of the National Academy of Sciences of the United States of America·Akinori KatoEduardo A Groisman
May 13, 1983·Science·S KirkpatrickM P Vecchi
Dec 14, 2007·Annual Review of Genetics·Michael T Laub, Mark Goulian
Dec 14, 2007·Proceedings of the National Academy of Sciences of the United States of America·Guy ShinarUri Alon
Mar 28, 2008·Molecular Microbiology·Oleg A IgoshinMichael A Savageau
Jun 24, 2008·Journal of Theoretical Biology·Simeone MarinoDenise E Kirschner
Sep 17, 2008·Advances in Experimental Medicine and Biology·Dagmar Beier, Roy Gross
Oct 4, 2008·Genes & Development·Alexander Y Mitrophanov, Eduardo A Groisman
Nov 7, 2008·Proceedings of the National Academy of Sciences of the United States of America·Tim Miyashiro, Mark Goulian
Oct 22, 2009·Physical Biology·Suman K BanikRahul V Kulkarni
Aug 13, 2010·Journal of the Royal Society, Interface·Attila Csikász-NagyOrkun S Soyer
Sep 24, 2013·Molecular BioSystems·Mahendra Kumar Prajapat, Supreet Saini
Mar 13, 2014·Nature Reviews. Microbiology·Jeffrey A MelvinPeggy A Cotter
Apr 5, 2014·The Journal of Chemical Physics·Srijeeta TalukderPinaki Chaudhury

❮ Previous
Next ❯

Citations

May 10, 2019·BMC Bioinformatics·Debangana ChakravortySudipto Saha

❮ Previous
Next ❯

Methods Mentioned

BETA
in vitro transcription
electrophoretic mobility shift assay

Related Concepts

Related Feeds

Bacterial Protein Structures (ASM)

Bacterial protein structures can expedite the development of novel antibiotics. Here is the latest research on bacterial proteins and the resolution of their structures.

Bacterial Protein Structures

Bacterial protein structures can expedite the development of novel antibiotics. Here is the latest research on bacterial proteins and the resolution of their structures.

Related Papers

Current Opinion in Microbiology
Robert B Bourret, Ruth E Silversmith
Revista chilena de infectología : órgano oficial de la Sociedad Chilena de Infectología
M Teresa Ulloa F
Nihon rinsho. Japanese journal of clinical medicine
Ryoichi Saito, Kazunari Kamachi
Nihon rinsho. Japanese journal of clinical medicine
T Konda, Y Arakawa
© 2021 Meta ULC. All rights reserved