Deciphering Pathways for Carotenogenesis in Haloarchaea

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Micaela GianiRosa María Martínez-Espinosa

Abstract

Bacterioruberin and its derivatives have been described as the major carotenoids produced by haloarchaea (halophilic microbes belonging to the Archaea domain). Recently, different works have revealed that some haloarchaea synthetize other carotenoids at very low concentrations, like lycopene, lycopersene, cis- and trans-phytoene, cis- and trans-phytofluene, neo-β-carotene, and neo-α-carotene. However, there is still controversy about the nature of the pathways for carotenogenesis in haloarchaea. During the last decade, the number of haloarchaeal genomes fully sequenced and assembled has increased significantly. Although some of these genomes are not fully annotated, and many others are drafts, this information provides a new approach to exploring the capability of haloarchaea to produce carotenoids. This work conducts a deeply bioinformatic analysis to establish a hypothetical metabolic map connecting all the potential pathways involved in carotenogenesis in haloarchaea. Special interest has been focused on the synthesis of bacterioruberin in members of the Haloferax genus. The main finding is that in almost all the genus analyzed, a functioning alternative mevalonic acid (MVA) pathway provides isopentenyl pyrophosphate (IPP) i...Continue Reading

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Citations

Nov 27, 2020·Biotechnology and Bioengineering·Lakshmi Kasirajan, Julie A Maupin-Furlow
Nov 4, 2020·Antioxidants·Micaela Giani, Rosa María Martínez-Espinosa
Aug 7, 2021·Biomolecules·Eric BernabeuCarmen Pire
Aug 27, 2021·Marine Drugs·Jamseel MoopantakathRosa María Martínez-Espinosa

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